ric-3 Antibody

Code CSB-PA631507XA01CXY
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Product Details

Full Product Name
Rabbit anti-Caenorhabditis elegans ric-3 Polyclonal antibody
Uniprot No.
Target Names
ric-3
Alternative Names
ric-3; des-5; T14A8.1; Resistance to inhibitors of cholinesterase protein 3
Raised in
Rabbit
Species Reactivity
Caenorhabditis elegans
Immunogen
Recombinant Caenorhabditis elegans ric-3 protein
Immunogen Species
Caenorhabditis elegans
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Required for maturation and cell surface expression of acetylcholine receptors.
Gene References into Functions
  1. RIC-3 phosphorylation at Ser-164 depends on opposing functions of the phosphatase calcineurin (TAX-6), and of the casein kinase II homologue KIN-10. RIC-3 phosphorylation enables effects of this chaperone on GABAA receptors in addition to nAChRs. PMID: 27489343
  2. The conserved residues in the second RIC-3 transmembrane domain are needed for its interactions with DEG-3,DES-2 and ACR-16. PMID: 19899809
  3. subunit-specific interactions of RIC-3 with nAChR subunits DEG-3/DES-2, mediated by the transmembrane domains, are sufficient for the effects of RIC-3 on nAChR quantity and quality PMID: 15932871
  4. RIC-3 alternative splicing enables subtype specific regulation of nicotinic acetylcholine receptor maturation. PMID: 19116311
Subcellular Location
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein Families
Ric-3 family
Tissue Specificity
Expressed in pharyngeal muscles, body wall muscles and in most neurons.
Database Links

KEGG: cel:CELE_T14A8.1

STRING: 6239.T14A8.1

UniGene: Cel.6773

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