Rrm1 Antibody

1. This study provides an improved understanding of the molecular basis (structure and dynamics) that governs the binding of the p54(nrb)/NonO RRM1 to one of its target RNAs. PMID: 27064654
2. This work reveals that binding of RRM1 to RRM2 is essential for mammalian cells and provides the first loss-of-function model of the ribonucleotide reductase complex for genetic studies. PMID: 26077802
3. analysis of transgenic overexpression of ribonucleotide reductase Rrm1 and Rrm2 improves cardiac performance PMID: 23530224
4. silencing RRM1 expression using siRNA could potentially be an effective strategy to overcome gemcitabine resistance. PMID: 22785206
5. Tip60-dependent recruitment of RNR plays an essential role in dNTP supply for DNA repair PMID: 20159953
6. The hexamer form of murine ribonucleotide reductase (mRR) large catalytic subunit mR1(6) predominates over the dimer form mR1(2) in the cytoplasm of normal cells, where the great majority of mRR activity is located. PMID: 12578384
7. overexpression of RRM1 in human and mouse lung cancer cell lines induced PTEN expression, reduced phosphorylation of focal adhesion kinase (FAK), suppressed migration, invasion, and metastasis formation, and increased survival in an animal model. PMID: 12687015

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KEGG: mmu:20133

STRING: 10090.ENSMUSP00000033283

UniGene: Mm.197486