Name: RNR1 Antibody
Brand: CUSABIO
SKU: CSB-PA321975XA01SVG

Product Details

Full Product Name	Rabbit anti-Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) RNR1 Polyclonal antibody
Uniprot No.	P21524
Target Names	RNR1
Alternative Names	RNR1 antibody; CRT7 antibody; RIR1 antibody; SDS12 antibody; YER070W antibody; Ribonucleoside-diphosphate reductase large chain 1 antibody; EC 1.17.4.1 antibody; Ribonucleotide reductase R1 subunit 1 antibody; Ribonucleotide reductase large subunit 1 antibody
Raised in	Rabbit
Species Reactivity	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Immunogen	Recombinant Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) RNR1 protein
Immunogen Species	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Conjugate	Non-conjugated
Clonality	Polyclonal
Isotype	IgG
Purification Method	Protein A/G
Concentration	It differs from different batches. Please contact us to confirm it.
Buffer	Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form	Liquid
Tested Applications	ELISA, WB (ensure identification of antigen)
Protocols	ELISA Protocol
Troubleshooting and FAQs	Antibody FAQs
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables	① 200ug * antigen (positive control); ② 1ml * Pre-immune serum (negative control);
Quality Guarantee	① Antibody purity can be guaranteed above 90% by SDS-PAGE detection; ② ELISA titer can be guaranteed 1: 64,000; ③ WB validation with antigen can be guaranteed positive;
Lead Time	Made-to-order (14-16 weeks)

Target Background

Function (From Uniprot)	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
Gene References into Functions	there is a directed orientation of the RNR beta and beta' C-terminal tails relative to alpha within the holoenzyme consistent with a docking model of the two subunits and argue against RT across the beta beta' interface PMID: 23532842 The data reveaedl that the arginine 293 and glutamine 288 residues of ribonucleotide reductase 1 are crucial in facilitating ADP and CDP substrate selection. PMID: 22465672 defects in autophagy result in an increase in soluble Rnr1 protein levels and a DNA damage phenotype. PMID: 21343333 Data show that Rnr1 transcription requires protein bound to a particular site and either five different sites or one additional sites. PMID: 21103376 The structures of the apo-, AMPPNP only-, AMPPNP-CDP-, AMPPNP-UDP-, dGTP-ADP- and TTP-GDP-bound complexes give insight into substrate and effector binding and specificity cross-talk. PMID: 16537479 x-ray structures upon binding to gemcitabine diphosphate PMID: 16537480 Show More Hide All
Subcellular Location	Cytoplasm.
Protein Families	Ribonucleoside diphosphate reductase large chain family
Database Links	KEGG: sce:YER070W STRING: 4932.YER070W

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RNR1 Antibody

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Code	CSB-PA321975XA01SVG
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