RNR1 Antibody

Code CSB-PA321975XA01SVG
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Product Details

Full Product Name Rabbit anti-Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) RNR1 Polyclonal antibody
Uniprot No. P21524
Target Names RNR1
Alternative Names RNR1 antibody; CRT7 antibody; RIR1 antibody; SDS12 antibody; YER070W antibody; Ribonucleoside-diphosphate reductase large chain 1 antibody; EC antibody; Ribonucleotide reductase R1 subunit 1 antibody; Ribonucleotide reductase large subunit 1 antibody
Raised in Rabbit
Species Reactivity Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Immunogen Recombinant Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) RNR1 protein
Immunogen Species Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Conjugate Non-conjugated
Clonality Polyclonal
Isotype IgG
Purification Method Protein A/G
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form Liquid
Tested Applications ELISA, WB (ensure identification of antigen)
Protocols ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables ① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee ① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time Made-to-order (14-16 weeks)

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Target Background

(From Uniprot)
Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
Gene References into Functions
  1. there is a directed orientation of the RNR beta and beta' C-terminal tails relative to alpha within the holoenzyme consistent with a docking model of the two subunits and argue against RT across the beta beta' interface PMID: 23532842
  2. The data reveaedl that the arginine 293 and glutamine 288 residues of ribonucleotide reductase 1 are crucial in facilitating ADP and CDP substrate selection. PMID: 22465672
  3. defects in autophagy result in an increase in soluble Rnr1 protein levels and a DNA damage phenotype. PMID: 21343333
  4. Data show that Rnr1 transcription requires protein bound to a particular site and either five different sites or one additional sites. PMID: 21103376
  5. The structures of the apo-, AMPPNP only-, AMPPNP-CDP-, AMPPNP-UDP-, dGTP-ADP- and TTP-GDP-bound complexes give insight into substrate and effector binding and specificity cross-talk. PMID: 16537479
  6. x-ray structures upon binding to gemcitabine diphosphate PMID: 16537480

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Subcellular Location Cytoplasm.
Protein Families Ribonucleoside diphosphate reductase large chain family
Database Links

KEGG: sce:YER070W

STRING: 4932.YER070W

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