rnf-5 Antibody

Datasheet

Code	CSB-PA141833XA01CXY
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Product Details
Customer Reviews and Q&A
Target Background

Product Details

Full Product Name

Rabbit anti-Caenorhabditis elegans rnf-5 Polyclonal antibody

Uniprot No.

Q09463

Target Names

rnf-5

Alternative Names

rnf-5 antibody; C16C10.7 antibody; E3 ubiquitin ligase rnf-5 antibody; EC 2.3.2.27 antibody; RING finger protein 5 antibody

Raised in

Rabbit

Species Reactivity

Caenorhabditis elegans

Immunogen

Recombinant Caenorhabditis elegans rnf-5 protein

Immunogen Species

Caenorhabditis elegans

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

E3 ubiquitin ligase that plays a role in the maintenance of muscle cell boundaries and muscle dense bodies, which establish the adhesion sites of the muscle cells to the extracellular matrix. Ubiquitinates the LIM domain protein unc-95, thereby regulating its dislocalization from muscle dense bodies and weakening the link between the muscle cells and the hypodermis. Regulation of unc-95 dissociation from muscle dense bodies by ubiquitination plays an important role in ecdysis during molting. Plays a role in the cessation of distal tip cell migration at the end of larval morphogenesis.

Gene References into Functions

These observations indicate that increased dense bodies (DB) dynamics characterizes the lethargus phase of molting in parallel to decreased levels of DB components and that temporal expression of RNF-5 contributes to an efficient molting process. PMID: 20385102
UNC-95 constitutes an essential component of muscle adhesion sites that is regulated by RNF-5. PMID: 15210732

Subcellular Location

Cell junction. Cell junction, focal adhesion. Cell membrane.

Tissue Specificity

Expressed in body wall muscles.

Database Links

STRING: 6239.C16C10.7

UniGene: Cel.7184

Promotions

Email: [email protected]
Distributors Worldwide

Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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