RNaseZ Antibody

Code CSB-PA847585XA01DLU
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Product Details

Full Product Name Rabbit anti-Drosophila melanogaster (Fruit fly) RNaseZ Polyclonal antibody
Uniprot No. Q8MKW7
Target Names RNaseZ
Alternative Names RNaseZ antibody; JhI-1 antibody; CG3298 antibody; Ribonuclease Z antibody; mitochondrial antibody; RNase Z antibody; EC antibody; Juvenile hormone-inducible protein 1 antibody; dRNAse Z antibody; tRNA 3 endonuclease antibody; DmeZ antibody; tRNase Z antibody
Raised in Rabbit
Species Reactivity Drosophila melanogaster (Fruit fly)
Immunogen Recombinant Drosophila melanogaster (Fruit fly) RNaseZ protein
Immunogen Species Drosophila melanogaster (Fruit fly)
Conjugate Non-conjugated
Clonality Polyclonal
Isotype IgG
Purification Method Protein A/G
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form Liquid
Tested Applications ELISA, WB (ensure identification of antigen)
Protocols ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables ① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee ① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time Made-to-order (14-16 weeks)

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Target Background

(From Uniprot)
Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity of nuclear and mitochondrial pre-tRNA. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA. May participate in tRNA processing in the developing embryo.
Gene References into Functions
  1. The linker region was explored by Ala-scanning through two conserved regions of D. melanogaster tRNase Z: NdomTprox, located at the carboxy end of the amino domain proximal to the linker, and Tflex, a flexible site in the linker. Periodic substitutions in a hydrophobic patch (F329 and L332) at the carboxy end of NdomTprox show 2,700 and 670-fold impairment relative to wild type PMID: 29045449
  2. The study implicates Drosophila RNase Z(L) in a novel retrograde signaling pathway initiated by the damage in mitochondria and manifested in a cell cycle delay before the mitotic entry. PMID: 26553808
  3. RNase Z(L) activity is essential for all phases of fly development that involve cell division, including growth of adult tissue progenitors during larval and metamorphic stages, and gametogenesis in adults. PMID: 23867108
  4. The study shows that dRNaseZ is necessary for 3'-end processing of nuclear & mitochondrial tRNAs. In mitotically growing imaginal discs it is required for cell proliferation and/or viability. In endoreplicating salivary glands, it controls organ size. PMID: 21146608
  5. conserved, functionally important residues within the His cluster of tRNase Z are thus involved in catalysis, but substrate recognition and binding functions must reside elsewhere in the protein. PMID: 15935379
  6. Residues in two homology blocks on the amino side of the tRNase Z His domain contribute unexpectedly to pre-tRNA 3' end processing PMID: 16618969

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Subcellular Location Nucleus. Mitochondrion.
Protein Families RNase Z family
Database Links

KEGG: dme:Dmel_CG3298

STRING: 7227.FBpp0087449

UniGene: Dm.2795

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