let-502 Antibody

Datasheet

Code	CSB-PA310884XA01CXY
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Product Details

Full Product Name

Rabbit anti-Caenorhabditis elegans let-502 Polyclonal antibody

Uniprot No.

P92199

Target Names

let-502

Alternative Names

let-502 antibody; C10H11.9 antibody; Rho-associated protein kinase let-502 antibody; EC 2.7.11.1 antibody; Lethal protein 502 antibody; Rho-binding kinase let-502 antibody

Raised in

Rabbit

Species Reactivity

Caenorhabditis elegans

Immunogen

Recombinant Caenorhabditis elegans let-502 protein

Immunogen Species

Caenorhabditis elegans

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

Negatively regulates mel-11 to relieve the inhibition of mlc-4, allowing contraction of the circumferentially oriented microfilaments in epidermal cells and thereby regulating myosin II contractility during spermathecal contraction, cleavage furrow contraction in early embryos, and embryonic elongation and morphogenesis. Required for P-cell migration. May also play a role in oocyte cellularization.

Gene References into Functions

MLC-4-containing myosin II is a Rho GTPase-regulated generator of contractility (of the myoepithelial sheath in the Caenorhabditis elegans somatic gonad) and that the two myosin II populations coordinate to produce actomyosin contractility for successful ovulation. PMID: 26864628
RHGF-2 acts through the Rho-binding kinase LET-502 to mediate embryonic elongation in C. elegans PMID: 26188247
pix-1 has a role in controlling early elongation in parallel with mel-11 and let-502 in Caenorhabditis elegans PMID: 24732978
Data describe nonmuscle myosins nmy-1 and nmy-2, which are components of the let-502/mel-11 pathway and assist in regulation of embryo elongation in C. elegans. PMID: 14522875
actomyosin-generated tension must be moderated in two out of the three sets of epidermal cells surrounding the C. elegans embryo to achieve morphogenesis PMID: 17537791
Data show that combined loss of ROCK and PAK, or ROCK and MRCK, completely prevented embryonic elongation, but a constitutively active form of MLC-4 could only rescue a lack of MRCK. PMID: 19675126

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Subcellular Location

Cytoplasm. Cytoplasm, cytoskeleton. Cleavage furrow.

Protein Families

Protein kinase superfamily, AGC Ser/Thr protein kinase family

Tissue Specificity

Expressed in the lateral hypodermal seam cells at the onset of the elongation phase of morphogenesis (at protein level).

Database Links

KEGG: cel:CELE_C10H11.9

STRING: 6239.C10H11.9

UniGene: Cel.5336

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Email: [email protected]
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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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let-502 Antibody

Product Details

Related Products

Customer Reviews and Q&A

Target Background