rpe65c Antibody

Code CSB-PA843402XA01DIL
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Product Details

Full Product Name
Rabbit anti-Danio rerio (Zebrafish) (Brachydanio rerio) rpe65c Polyclonal antibody
Uniprot No.
Target Names
rpe65c
Alternative Names
rpe65c antibody; si:ch211-198n5.12 antibody; Retinal Mueller cells isomerohydrolase antibody; EC 3.1.1.64 antibody; All-trans-retinyl ester 13-cis isomerohydrolase C antibody; EC 3.1.1.90 antibody; All-trans-retinylester 11-cis isomerohydrolase C antibody; Lutein isomerase antibody; Meso-zeaxanthin isomerase antibody; EC 5.3.3.22 antibody; Retinal pigment epithelium-specific 65 kDa protein homolog C antibody; RPE56c antibody
Raised in
Rabbit
Species Reactivity
Danio rerio (Zebrafish) (Brachydanio rerio)
Immunogen
Recombinant Danio rerio (Zebrafish) (Brachydanio rerio) rpe65c protein
Immunogen Species
Danio rerio (Zebrafish) (Brachydanio rerio)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Catalyzes both 11-cis retinol and 13-cis retinol, 2 stereoisomeric forms of retinoic acid from all-trans-retinyl ester. Acts as an alternative isomerohydrolase in retinal Mueller cells by catalyzing formation of 11-cis retinol, to meet the high demand for the chromophore by cones. Capable of catalyzing the isomerization of lutein to meso-zeaxanthin an eye-specific carotenoid.
Gene References into Functions
  1. these results showed that residue 58 is a primary determinant of isomerization specificity, because the Y58N mutation in RPE65c and its reciprocal N58Y mutation in 13cIMH completely reversed the respective enzyme isomerization product specificities. PMID: 22512451
Subcellular Location
Cytoplasm. Cell membrane; Lipid-anchor.
Protein Families
Carotenoid oxygenase family
Tissue Specificity
Retinal Mueller cells. Detected in the inner retina near the ganglion cell layer, in a region where the Mueller end feet are located, and a weak signal is observed between the outer nuclear and ganglion cell layers (at protein level).
Database Links
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Call us
301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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