cI Antibody

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Code	CSB-PA355929XA01FSF
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Target Background

Product Details

Full Product Name

Rabbit anti-Escherichia phage lambda (Bacteriophage lambda) cI Polyclonal antibody

Uniprot No.

P03034

Target Names

Alternative Names

cI antibody; lambdap88 antibody; Repressor protein cI antibody

Raised in

Rabbit

Species Reactivity

Escherichia phage lambda (Bacteriophage lambda)

Immunogen

Recombinant Escherichia phage lambda (Bacteriophage lambda) cI protein

Immunogen Species

Escherichia phage lambda (Bacteriophage lambda)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

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Target Background

Function

Acts as a transcriptional repressor that allows virus to establish and maintain latency. Prevents both the viral DNA replication and the exit programs. Clamps the two operator OL (operator left made of OL1, OL2 and OL3 sites) and OR (operator right made of OR1, OR2 and OR3 sites) together by binding to them and arranging the intervening DNA in a loop. This step allows repression of lytic pR and pL promoters by binding to OL1, OL2, OR1 and OR2 simultaneously. The binding of cI on OR2 additionally activates the transcription of the cI gene thereby mediating an autoregulatory function to maintain the latent state. Once cI is present in sufficient amount, it can repress its own transcription by binding to OL3 and OR3.

Gene References into Functions

Enterobacteria phage lambda repressor fragment (6-85) takes only microseconds to reach its native state from an extensively unfolded state, while the latter takes milliseconds to reach compact beta-rich traps. PMID: 22066714
Temperature-dependent interactions (e.g., hydrophobicity) play a large role in the initial stages of folding of lambda repressor N-terminal domain (residues 6-85) but not in the initial stages of unfolding. PMID: 15476395
Two-state folding of lambda(6-85) is not a robust process. PMID: 17075136
NMR was used to characterize the secondary structure and dynamics of MetO-lambdaLS in standard phosphate buffer PMID: 17260944

Database Links

KEGG: vg:3827059

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