rtcb-1 Antibody

Code CSB-PA003810XA01CXY
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Product Details

Full Product Name
Rabbit anti-Caenorhabditis elegans rtcb-1 Polyclonal antibody
Uniprot No.
Target Names
rtcb-1
Alternative Names
rtcb-1 antibody; F16A11.2 antibody; RNA-splicing ligase RtcB homolog antibody; EC 6.5.1.8 antibody; 3'-phosphate/5'-hydroxy nucleic acid ligase antibody
Raised in
Rabbit
Species Reactivity
Caenorhabditis elegans
Immunogen
Recombinant Caenorhabditis elegans rtcb-1 protein
Immunogen Species
Caenorhabditis elegans
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs. Required for the ligation of mRNAs and specifically, regulates xbp-1 mRNA splicing during the endoplasmic reticulum stress-induced unfolded protein response. Has a neuroprotective role in the age-dependent degeneration of dopamine neurons, which is mediated by xbp-1.
Gene References into Functions
  1. Data indicate that neuronal RNA ligase RtcB activity as a critical regulator of neuronal growth potential. PMID: 26100902
Subcellular Location
Nucleus. Cytoplasm.
Protein Families
RtcB family
Database Links

KEGG: cel:CELE_F16A11.2

STRING: 6239.F16A11.2

UniGene: Cel.24992

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