RTR1 Antibody

Datasheet

Code	CSB-PA328070XA01SVG
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Product Details

Full Product Name

Rabbit anti-Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) RTR1 Polyclonal antibody

Uniprot No.

P40084

Target Names

RTR1

Alternative Names

RTR1 antibody; YER139C antibody; RNA polymerase II subunit B1 CTD phosphatase RTR1 antibody; EC 3.1.3.16 antibody; RNA polymerase II-associated protein 2 homolog RTR1 antibody; Regulator of transcription 1 antibody

Raised in

Rabbit

Species Reactivity

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Immunogen

Recombinant Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) RTR1 protein

Immunogen Species

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

RNA polymerase II subunit B1 C-terminal domain (CTD) phosphatase that dephosphorylates 'Ser-5' of the CTD and regulates RNA polymerase II during the transition from 'Ser-5' to 'Ser-2' phosphorylation.

Gene References into Functions

Findings show that Rtr1 is a global regulator of the C-terminal domain (CTD) code with deletion of RTR1 causing genome-wide changes in Ser5-P CTD phosphorylation and cotranscriptional histone H3 lysine 36 trimethylation. PMID: 27247267
Data indicate that the structure of the phosphoryl transfer domain and reaction mechanism for the phosphoryl transfer activity of regulator of transcription 1 (Rtr1) is distinct from those of other phosphatase families. PMID: 26933063
Rtr1p may imprint its RNA targets cotranscriptionally and determine their downstream degradation mechanism by directing these transcripts to a novel turnover pathway that involves Rtr1p, Dhh1p, and the REX family of exonucleases. PMID: 26843527
Studies revealed that hyperphosphorylated RNAPII is the primary interacting partner for Rtr1. PMID: 24671508
YER139C encodes the closest yeast homolog of the human RPAP2 protein, recently identified as a novel RNA polymerase II (RNAPII)-associated factor. PMID: 18408053
Rtr1 functions as a CTD phosphatase essential for the Serine5-to-Serine2-Phosphorylation transition. PMID: 19394294

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Subcellular Location

Cytoplasm. Nucleus. Note=Shuttles constitutively between the cytoplasm and the nucleus.

Protein Families

RPAP2 family

Database Links

KEGG: sce:YER139C

STRING: 4932.YER139C

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Email: [email protected]
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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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RTR1 Antibody

Product Details

Related Products

Customer Reviews and Q&A

Target Background