ruvb-2 Antibody

Code CSB-PA123725XA01CXY
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Product Details

Full Product Name
Rabbit anti-Caenorhabditis elegans ruvb-2 Polyclonal antibody
Uniprot No.
Target Names
ruvb-2
Alternative Names
ruvb-2 antibody; T22D1.10 antibody; RuvB-like 2 antibody; EC 3.6.4.12 antibody; Reptin antibody
Raised in
Rabbit
Species Reactivity
Caenorhabditis elegans
Immunogen
Recombinant Caenorhabditis elegans ruvb-2 protein
Immunogen Species
Caenorhabditis elegans
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)
Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function
Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (5' to 3') activity suggesting a role in nuclear processes such as recombination and transcription. May participate in several chromatin remodeling complexes that mediate the ATP-dependent exchange of histones and remodel chromatin by shifting nucleosomes. Involvement in these complexes is likely required for transcriptional activation of selected genes and DNA repair in response to DNA damage. Has a role in gonadal development. Involved in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway where it negatively regulates expression of ER stress response genes. Specifically, negatively controls the expression of ER homeostasis regulator ckb-2 in a cdc-48.1/2-dependent manner.
Subcellular Location
Cytoplasm. Nucleus.
Protein Families
RuvB family
Tissue Specificity
Expressed in gonadal cells.
Database Links
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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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