lin-18 Antibody

Code CSB-PA179793XA01CXY
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Product Details

Full Product Name
Rabbit anti-Caenorhabditis elegans lin-18 Polyclonal antibody
Uniprot No.
Target Names
lin-18
Alternative Names
lin-18 antibody; ryk antibody; C16B8.1 antibody; Inactive tyrosine-protein kinase RYK antibody; Abnormal cell lineage protein 18 antibody
Raised in
Rabbit
Species Reactivity
Caenorhabditis elegans
Immunogen
Recombinant Caenorhabditis elegans lin-18 protein
Immunogen Species
Caenorhabditis elegans
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Has no detectable kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo. Receptor which may act as a receptor for Wnt ligand mom-2. Plays a role in controlling P7.p vulva precursor cell lineage orientation during vulva development. Regulates pop-1 asymmetric distribution in P7.p and its daughter cells. Plays a role in the migration of ALM neurons during embryogenesis.
Gene References into Functions
  1. Ryk-intracellular domain fragment suppressed neuroprotection by lin-18/Ryk loss-of-function in expanded-polyQ nematodes, repressed FOXO transcriptional activity, and abolished beta-catenin protection of mutant htt striatal cells against cell death PMID: 24960609
  2. Release of LIN-18ICD by cleavage at the membrane is not the main mechanism of LIN-18 signaling in vulval cells. results suggest LIN-18 intracellular domain interacts with Wnt pathway and a 14-3-3 protein and likely plays a minor role in LIN-18 signaling PMID: 24975394
  3. LIN-18 encodes a member of the Ryk/Derailed family of tyrosine kinase-related receptors, recently found to function as Wnt receptors. Members of this family have nonactive kinase domains PMID: 15369677
Subcellular Location
Cell membrane; Single-pass type I membrane protein. Basolateral cell membrane; Single-pass type I membrane protein.
Protein Families
Protein kinase superfamily, Tyr protein kinase family
Database Links

KEGG: cel:CELE_C16B8.1

STRING: 6239.C16B8.1.2

UniGene: Cel.19586

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