sox17a-b Antibody

Code CSB-PA845897XA01XBE
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Product Details

Full Product Name
Rabbit anti-Xenopus laevis (African clawed frog) sox17a-b Polyclonal antibody
Uniprot No.
Target Names
sox17a-b
Alternative Names
sox17a-b antibody; sox17a2Transcription factor Sox-17-alpha-B antibody; xSox17alpha2 antibody
Raised in
Rabbit
Species Reactivity
Xenopus laevis (African clawed frog)
Immunogen
Recombinant Xenopus laevis (African clawed frog) sox17a-b protein
Immunogen Species
Xenopus laevis (African clawed frog)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Transcription activator. Binds to the DNA sequence 5'-AACAAT-3'. All of the sox17 proteins are required for embryonic endoderm development and gastrulation movements, and show some redundancy in function. In addition, the sox17 proteins have distinct but overlapping roles in later gut development. Acts downstream of vegt-signaling in endoderm differentiation to induce a range of endodermal genes both directly (including endodermin and dhh/chh) and indirectly. Also represses wnt-responsive genes to inhibit wnt/beta-catenin signaling.
Subcellular Location
Nucleus.
Tissue Specificity
Enriched in the embryonic endoderm. Expressed in the embryonic gut, with strong expression in the posterior gut during tailbud stages. Expressed at a low level in the adult kidney and spleen.
Database Links

KEGG: xla:398765

UniGene: Xl.11957

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