sox17b.1 Antibody

Code CSB-PA520363XA01XBE
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Product Details

Full Product Name
Rabbit anti-Xenopus laevis (African clawed frog) sox17b.1 Polyclonal antibody
Uniprot No.
Target Names
sox17b.1
Alternative Names
sox17b.1 antibody; sox17b antibody; Transcription factor Sox-17-beta.1 antibody; SRY antibody; sex determining region Y)-box 17-beta.1 antibody; Transcription factor Sox-17-beta antibody; XSox17beta antibody
Raised in
Rabbit
Species Reactivity
Xenopus laevis (African clawed frog)
Immunogen
Recombinant Xenopus laevis (African clawed frog) sox17b.1 protein
Immunogen Species
Xenopus laevis (African clawed frog)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Transcription activator. Doesn't appear to bind to the consensus 5'-AACAAT-3' DNA binding site, but binds 5'-ATTGTT-3'. All of the sox17 proteins are required for embryonic endoderm development and gastrulation movements, and show some redundancy in function. In addition, the sox17 proteins have distinct but overlapping roles in later gut development. Acts downstream of vegt-signaling in endoderm differentiation to induce a range of endodermal genes both directly and indirectly. Also represses wnt-responsive genes to inhibit wnt/beta-catenin-mediated signaling.
Subcellular Location
Nucleus.
Tissue Specificity
In early gastrulae, expressed in the vegetal but not animal hemisphere. The vegetal region is fated to become endoderm and endodermal expression continues throughout gastrulation and neurulation. At tailbud stages, expression is barely detectable.
Database Links

KEGG: xla:397967

UniGene: Xl.44

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