san Antibody

Datasheet

Code	CSB-PA882048XA01DLU
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Target Background

Product Details

Full Product Name

Rabbit anti-Drosophila melanogaster (Fruit fly) san Polyclonal antibody

Uniprot No.

Q9NHD5

Target Names

san

Alternative Names

san antibody; span antibody; CG12352 antibody; Probable N-acetyltransferase san antibody; EC 2.3.1.258 antibody; N-epsilon-acetyltransferase san antibody; EC 2.3.1.- antibody; Protein atado antibody; Protein separation anxiety antibody

Raised in

Rabbit

Species Reactivity

Drosophila melanogaster (Fruit fly)

Immunogen

Recombinant Drosophila melanogaster (Fruit fly) san protein

Immunogen Species

Drosophila melanogaster (Fruit fly)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

N-alpha-acetyltransferase that acetylates the N-terminus of proteins that retain their initiating methionine. Has a broad substrate specificity: able to acetylate the initiator methionine of most peptides. Also displays N-epsilon-acetyltransferase activity by mediating acetylation of the side chain of specific lysines on proteins. Autoacetylates. Required for the establishment of sister chromatid cohesion and couple the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. Required for the interaction between Scc1/vtd and SMC3, possibly by mediating N-terminal acetylation of Scc1/vtd.; (Microbial infection) Required for optimal replication of E.chaffeensis in the immune tissues, hemocytes, and fat body.

Gene References into Functions

Results suggest that during tissue proliferation San behaves as general regulator of sister chromatid cohesion, as it facilitates the correct interaction between cohesin subunits Scc1/Rad21/Vtd and Smc3. Also, the results suggest a working model where Naa50/San N-terminally acetylates the nascent Scc1 polypeptide, which is subsequently required for the correct establishment and maintenance of sister chromatid cohesion. PMID: 27996020
plays vital roles in regulating sister chromatid cohesion during Drosophila mitosis PMID: 14653991
san is required in vivo for normal mitosis of different types of somatic cells. PMID: 18801358

Subcellular Location

Cytoplasm.

Protein Families

Acetyltransferase family

Database Links

KEGG: dme:Dmel_CG12352

STRING: 7227.FBpp0087227

UniGene: Dm.1821

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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san Antibody

Product Details

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Target Background