cho-1 Antibody

Code CSB-PA516867XA01CXY
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Product Details

Full Product Name
Rabbit anti-Caenorhabditis elegans cho-1 Polyclonal antibody
Uniprot No.
Target Names
cho-1
Alternative Names
cho-1 antibody; C48D1.3 antibody; High-affinity choline transporter 1 antibody
Raised in
Rabbit
Species Reactivity
Caenorhabditis elegans
Immunogen
Recombinant Caenorhabditis elegans cho-1 protein
Immunogen Species
Caenorhabditis elegans
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Imports choline from the extracellular space to the neuron with high affinity. Choline uptake is the rate-limiting step in acetylcholine synthesis. Sodium ion and chloride ion dependent.
Gene References into Functions
  1. Studies to determine the impact of gene mutations on the trafficking of the Caenorhabditis elegans choline transporter orthologue revealed deficits in transporter export to axons and nerve terminals. PMID: 29088354
  2. Although homozygous cho-1 null mutants are viable, they possess 40% less Acetylcholine than wild-type and display stress-dependent defects in motor activity. PMID: 16763028
Subcellular Location
Membrane; Multi-pass membrane protein.
Protein Families
Sodium:solute symporter (SSF) (TC 2.A.21) family
Tissue Specificity
Detected in the nervous system, including the nerve ring and cholinergic motor neurons of the ventral nerve cord.
Database Links

KEGG: cel:CELE_C48D1.3

STRING: 6239.C48D1.3

UniGene: Cel.19528

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