sca Antibody

Datasheet

Code	CSB-PA324208XA01DLU
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Target Background

Product Details

Full Product Name

Rabbit anti-Drosophila melanogaster (Fruit fly) sca Polyclonal antibody

Uniprot No.

P21520

Target Names

sca

Alternative Names

sca antibody; CG17579 antibody; Protein scabrous antibody

Raised in

Rabbit

Species Reactivity

Drosophila melanogaster (Fruit fly)

Immunogen

Recombinant Drosophila melanogaster (Fruit fly) sca protein

Immunogen Species

Drosophila melanogaster (Fruit fly)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

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Target Background

Function

Involved in regulation of neurogenesis. May encode a lateral inhibitor of R8 differentiation. In conjunction with Gp150, promotes Notch activation in response to Delta by regulating acquisition of insensitivity to Delta in a subset of cells.

Gene References into Functions

These and other results obtained with a reporter line of Notch activity indicate that sca overexpression antagonizes Notch signaling in the Drosophila eye, and are inconsistent with Sca being an ommatidial rotation-specific factor. PMID: 26505171
Scabrous is an activator that can overcome the sensitivity of template-based lateral inhibition to spatial variations in biochemical parameters and cell sizes in eye development. PMID: 26876750
Scabrous controls the stop of ommatidial rotation by suppressing nemo activity in the second 45 degrees rotation. The morphogenetic furrow regulates precise ommatidial rotation by transporting Scabrous through actin-based cellular extensions. PMID: 12479809

Subcellular Location

Late endosome. Note=Colocalizes in late endosomes with Gp150.

Database Links

KEGG: dme:Dmel_CG17579

STRING: 7227.FBpp0086969

UniGene: Dm.4735

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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sca Antibody

Product Details

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Customer Reviews and Q&A

Target Background