scc-3 Antibody

Datasheet

Code	CSB-PA203434XA01CXY
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Product Details
Customer Reviews and Q&A
Target Background

Product Details

Full Product Name

Rabbit anti-Caenorhabditis elegans scc-3 Polyclonal antibody

Uniprot No.

Q19555

Target Names

scc-3

Alternative Names

scc-3 antibody; F18E2.3 antibody; Cohesin subunit scc-3 antibody

Raised in

Rabbit

Species Reactivity

Caenorhabditis elegans

Immunogen

Recombinant Caenorhabditis elegans scc-3 protein

Immunogen Species

Caenorhabditis elegans

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Customer Reviews and Q&A

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Target Background

Function

Component of the cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the scc-1 subunit of the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Plays an essential role in cell division during embryonic development. Required for the assembly of the synaptonemal complex between homologous chromosomes to promote sister chromatid cohesion during mitosis and meiosis. Has a role in stabilization of homologous chromosome associations during meiotic synapsis. Required for chromosome segregation during mitosis and meiosis. Plays a role in DNA double-strand break (DSB) repair during meiotic recombination and promotes the assembly of the 9-1-1 cell-cycle checkpoint response complex which is required for inducing apoptosis in response to DNA damage, at DNA damage sites.

Gene References into Functions

Cytological localization and the consequences of the lack of the protein indicate that C. elegans SCC-3 is essential for sister chromatid cohesion both in mitosis and in meiosis. PMID: 14499625
These results indicate that EVL-14/PDS-5 and SCC-3 have functions in both mitosis and meiosis. PMID: 14560015

Subcellular Location

Nucleus. Chromosome.

Protein Families

SCC3 family

Tissue Specificity

Expressed in gonadal cells.

Database Links

KEGG: cel:CELE_F18E2.3

STRING: 6239.F18E2.3

UniGene: Cel.7411

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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