NaCP60E Antibody

Datasheet

Code	CSB-PA892926XA01DLU
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Product Details

Full Product Name

Rabbit anti-Drosophila melanogaster (Fruit fly) NaCP60E Polyclonal antibody

Uniprot No.

Q9W0Y8

Target Names

NaCP60E

Alternative Names

NaCP60E antibody; DIC60 antibody; DSC1 antibody; smi60E antibody; CG34405 antibody; Sodium channel protein 60E antibody; Drosophila ion channel 60 antibody; Drosophila sodium channel 1 antibody; Protein smell-impaired 60E antibody; Sodium channel 2 antibody; DmNav2 antibody

Raised in

Rabbit

Species Reactivity

Drosophila melanogaster (Fruit fly)

Immunogen

Recombinant Drosophila melanogaster (Fruit fly) NaCP60E protein

Immunogen Species

Drosophila melanogaster (Fruit fly)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

Mediates the voltage-dependent sodium ion permeability of excitable membranes. Plays a role in processing of olfactory information during the olfactory avoidance response.

Gene References into Functions

We summarize major findings from recent studies and highlight a unique role of the DSC1 channel, distinct from that of the sodium channel, in regulating membrane excitability and modulating toxicity of pyrethroid insecticides PMID: 25987218
These results reveal an important role of the DSC1 channel in modulating the stability of neural circuits, particularly under environmental stresses, likely by maintaining the sustainability of synaptic transmission. PMID: 23505382
DSC1 channels are expressed in both the central and the peripheral nervous system of adult Drosophila melanogaster. PMID: 12488978
These results identify nebula/DSCR1 as a regulator of mitochondrial function and integrity and further suggest that an increased level of DSCR1 may contribute to the mitochondrial dysfunction seen in Down syndrome. PMID: 16222229
This study showed that transcripts lacking all cytoplasmic alternatively spliced exons still produce functional channels' PMID: 19625535

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Subcellular Location

Cell membrane; Multi-pass membrane protein.

Protein Families

Sodium channel (TC 1.A.1.10) family, NaCP60E subfamily

Tissue Specificity

In embryonic and larval stages, expression is limited to very few non-neuronal cells in either the CNS or PNS. In pupal and adult stages, expressed in cell bodies of the fly central nervous system, including optic lobes, central brain, subesophageal gangl

Database Links

KEGG: dme:Dmel_CG34405

STRING: 7227.FBpp0303273

UniGene: Dm.20002

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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NaCP60E Antibody

Product Details

Related Products

Customer Reviews and Q&A

Target Background