Scr Antibody

Datasheet

Code	CSB-PA362586XA01DLU
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Target Background

Product Details

Full Product Name

Rabbit anti-Drosophila melanogaster (Fruit fly) Scr Polyclonal antibody

Uniprot No.

P09077

Target Names

Scr

Alternative Names

Scr antibody; CG1030 antibody; Homeotic protein Sex combs reduced antibody

Raised in

Rabbit

Species Reactivity

Drosophila melanogaster (Fruit fly)

Immunogen

Recombinant Drosophila melanogaster (Fruit fly) Scr protein

Immunogen Species

Drosophila melanogaster (Fruit fly)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

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Target Background

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Controls the segmental transformation of the first to the second thoracic segment (prothorax to mesothorax) and of the labial palps into maxillary palps. In embryo, required for fusion of labial lobes and development of the T1 denticle belt. In adult, expression in the head is necessary for proper development of the labium. In the first thoracic segment of the adult, required for proper development of the sex comb and to suppress improper prothoracic wing development.

Gene References into Functions

Results from NMR spectroscopy show that spontaneous deamidation of Scr protein at residue Asn 321 reduces its affinity for target DNA. PMID: 26435141
To test if Hox proteins directly use shape readout, study characterized Exd-Scr co-crystal structures. When minor groove-inserting residues of Scr were mutated to alanines, thus impairing its ability to use shape readout, the mutant proteins no longer preferred sequences containing these minor groove width minima. PMID: 25843630
male-like pattern of SCR expression is independent of dsx function, and dsx F must be responsible for bringing about dimorphism in SCR expression, whereas dsx M function is required with Scr for the morphogenesis of sex comb. PMID: 23938378
Dynamic changes in Sex comb reduced protein expression are responsible for the diversity seen in sex comb morphology. PMID: 23197370
Results indicate that Scr functions as a homodimer to increase its transcriptional specificity and suggest that the formation of homeodomain (HD) homo- or heterodimers might underlie the functional distinction between very similar HD proteins in vivo. PMID: 22564794
alteration in Scr expression expands or contracts the doublesex domain, and vice versa PMID: 21886483
proteins bound at a pair of regulatory elements flanking the Scr promoter interact to stablize silencing PMID: 12072469
identified new cis-regulatory DNAs in the approximately 50-kb Scr-Antp interval PMID: 12909726
Scr gene expression is influenced by direct interaction between DSP1 and two Scr regulation elements PMID: 15610064
Results describe the sex-specific regulation of a Sex combs reduced, a HOX gene contributing to the development and evolution of a secondary sexual trait. PMID: 17868668
Differences in sex comb numbers reflect changes of Scr expression in tarsus primordia in Drosophila. PMID: 18184363

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Subcellular Location

Nucleus.

Protein Families

Antp homeobox family, Deformed subfamily

Tissue Specificity

In embryo, expressed in the labial and anterior prothoracic segments and the extreme posterior of the maxillary segment. In adult, expressed in the maxillary analgen of the eye and antennal imaginal disk and the labial and T1 leg imaginal disks.

Database Links

KEGG: dme:Dmel_CG1030

STRING: 7227.FBpp0089393

UniGene: Dm.2481

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Scr Antibody

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Target Background