secB Antibody

Datasheet

Code	CSB-PA314178XA01ENV
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Target Background

Product Details

Full Product Name

Rabbit anti-Escherichia coli (strain K12) secB Polyclonal antibody

Uniprot No.

P0AG86

Target Names

secB

Alternative Names

secB antibody; b3609 antibody; JW3584 antibody; Protein-export protein SecB antibody; Chaperone SecB antibody

Raised in

Rabbit

Species Reactivity

Escherichia coli (strain K12)

Immunogen

Recombinant Escherichia coli (strain K12) secB protein

Immunogen Species

Escherichia coli (strain K12)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

One of the proteins required for the normal export of some preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. For 2 proteins (MBP, MalE and PhoA) the substrate is wrapped around the homotetramer, which prevents it from folding. It also specifically binds to its receptor SecA. Its substrates include DegP, FhuA, FkpA, GBP, LamB, MalE (MBP), OmpA, OmpF, OmpT, OmpX, OppA, PhoE, TolB, TolC, YbgF, YcgK, YgiW and YncE.

Gene References into Functions

the primary role of SecB is to facilitate the targeting of secretory proteins to the Sec-translocase PMID: 16352602
SecB residues involved in contacts with the unfolded form of bound precursor, galactose-binding protein, are identified as those that upon addition of the unfolded polypeptide ligand show changes in spectral line shape. PMID: 16962134
effect of chaperone SecB on folding & unfolding pathways of maltose binding protein at the single-molecule level; interactions with SecB prevent stable tertiary contacts in core structure but have no detectable effect on folding of external alpha helices PMID: 18048690
SecB exhibits the remarkable ability to bind a diverse group of ligands recognizing them by virtue of the fact that they have non-native structure. PMID: 19569227

Subcellular Location

Cytoplasm.

Protein Families

SecB family

Database Links

KEGG: ecj:JW3584

STRING: 316385.ECDH10B_3791

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

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Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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secB Antibody

Product Details

Related Products

Customer Reviews and Q&A

Target Background