sek-1 Antibody

Dual specificity protein kinase which acts as an essential component of the p38 signal transduction pathway which is also composed of upstream effector nsy-1 and downstream effector pmk-1. May phosphorylate pmk-1. Downstream of CaMKII unc-43 and adapter protein tir-1, plays a role in determining asymmetric cell fates in olfactory AWC neurons during neuronal development. Activation results in the repression of odorant receptor str-2 expression in one of the 2 AWC neurons. Involved in resistance to pathogenic Gram-positive and Gram-negative bacterial and fungal infection. Involved in resistance to the nematotoxic C.cinerea galectin Cgl2. Probably by promoting pmk-1-mediated activation of skn-1, involved in the up-regulation of gcs-1 and glutathione-S-transferase gst-4 expression upon bacterial infection. Probably downstream of tir-1, required for the expression of antimicrobial peptide nlp-29 in the epidermis in response to fungal infection or physical injury. Regulates susceptibility of B.thuringiensis pore-forming toxin Cry5B and Cry21A. Involved in the response to oxidative stress. May regulate transcription factor daf-16 localization during oxidative stress. By phosphorylating pmk-1, regulates skn-1 localization during oxidative stress. By phosphorylating and activating pmk-1, plays a role in the stabilization of transcription factor rnt-1 in the intestine during oxidative stress. Up-regulates expression of gcs-1 in intestine upon arsenite treatment. Regulates germline proliferation in response to osmotic stress, starvation and germline apoptosis induced by heavy metals, such as Cu(2+). In association with mek-1, regulates germline cell apoptosis in response to oxidative, osmotic and heat shock stresses. Plays a role downstream of tir-1/nsy-1 in regulating susceptibility to anoxia. In males, by regulating pqn-41 expression, involved in non-apoptotic death of the linker cell which guides gonad elongation during larval development. Involved in egg laying.