Sema1a Antibody

1. The PDZ domain binding motif found in the most C-terminal region of the Sema-1a ICD is necessary for interaction with Vari, but not Cher, indicative of distinct binding modalities. Pbl/Sema-1a-mediated repulsive guidance is potentiated by both vari and cher Genetic analyses further suggest that scaffolding functions of Vari and Cher play an important role in Pbl-mediated Sema-1a reverse signaling. PMID: 28894005
2. The transmembrane proteins semaphorin-1a (Sema-1a) and plexin A function together to regulate ellipsoid body laminated ring (R) neuron axon lamination. PMID: 28632130
3. Sema-1a reverse signaling can elicit distinct axonal responses depending on differential engagement of distinct ligands and signaling effectors. PMID: 28052247
4. Sema1a and Dscam1 might play essential roles in the Drosophila DA1 ventral olfactory projection neurons morphogenesis. PMID: 27163287
5. these results demonstrate that Sema-1a repulsion keeps dendrites of different types of PNs away from each other, enabling the same types of PN dendrites to be sorted into destined AL glomeruli and permitting for functional assembly of olfactory circuitry. PMID: 28448523
6. The authors show that PlexA/Sema1a mediates motoneuron axon branching in ways that differ in the proximal femur and distal tibia, based on motoneuronal birth order. PMID: 26926907
7. A novel mechanism underlying upregulation of axon-axon attraction by Semaphorin-1a (Sema1a) reverse signaling in the developing Drosophila visual system, is reported. PMID: 25049408
8. This study demonistrated that the transmembrane guidance cue Sema-1a regulates axon-axon interactions, providing insight into links between guidance cue recognition and subsequent intracellular signaling events. PMID: 23177958
9. Sema1a and netrin A can specifically promote growth through induction of key cellular growth regulators. PMID: 20162636
10. By co-expressing shibire(ts) and semaphorin 1a, data show that semaphorin 1a was one of the proteins being regulated by endocytosis and its removal was a necessary part of the program for synaptogenesis. PMID: 12835384
11. Nervy couples cAMP-PKA signaling to Plexin A to regulate Semaphorin 1a-mediated axonal repulsion PMID: 14976319
12. The function of Sema1a in R-cell axon guidance absolutely requires its cytoplasmic domain and functions as a receptor in regulating R-cell axon guidance in the Drosophila visual system. PMID: 16611816
13. Thus, graded expression of Sema-1a contributes to connection specificity from ORNs to PNs and then to higher brain centers, ensuring proper representation of olfactory information in the brain. PMID: 17254975

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KEGG: dme:Dmel_CG18405

STRING: 7227.FBpp0302962

UniGene: Dm.13264