Ser Antibody

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Code	CSB-PA323572XA01DLU
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Target Background

Product Details

Full Product Name

Rabbit anti-Drosophila melanogaster (Fruit fly) Ser Polyclonal antibody

Uniprot No.

P18168

Target Names

Ser

Alternative Names

Ser antibody; Bd antibody; CG6127 antibody; Protein serrate antibody; Protein beaded antibody

Raised in

Rabbit

Species Reactivity

Drosophila melanogaster (Fruit fly)

Immunogen

Recombinant Drosophila melanogaster (Fruit fly) Ser protein

Immunogen Species

Drosophila melanogaster (Fruit fly)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

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Target Background

Function

Acts as a ligand for Notch (N) receptor. Essential for proper ectodermal development. Serrate represents an element in a network of interacting molecules operating at the cell surface during the differentiation of certain tissues.

Gene References into Functions

EGF-like repeat region is responsible for both cis-inhibition and Notch inhibitory properties associated with secreted forms of Serrate. PMID: 23571220
794 bp cis-regulatory element located in the 3' region of the Ser gene can recapitulate the dynamic patterns of endogenous Ser expression during wing development PMID: 14701680
two mutations can be separated by meiotic recombination which restores the Ser(D) mutant phenotype and demonstrates that in the absence of Ser(D) the Ser(+r83k) mutation is homozygous lethal PMID: 15124226
Ser regulates a wide variety of essential cell-fate decisions during animal development. PMID: 15760269
Neuralized physically associates with Serrate and stimulates its endocytosis and signaling activity. PMID: 16093323
Lobe (L) and the Notch (N) ligand Serrate (Ser), which are both involved in ventral eye growth, are required for cell survival in the early eye disc. PMID: 17090721
Loss of Stat92E led to de-repression of Serrate in the dorsal eye, resulting in ectopic Notch signaling and aberrant eye growth there. PMID: 19504457

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Subcellular Location

Membrane; Single-pass type I membrane protein.

Tissue Specificity

Restricted exclusively to cells of ectodermal origin.

Database Links

KEGG: dme:Dmel_CG6127

STRING: 7227.FBpp0084498

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Ser Antibody

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