set-25 Antibody

Datasheet

Code	CSB-PA948487XA01CXY
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Product Details
Customer Reviews and Q&A
Target Background

Product Details

Full Product Name

Rabbit anti-Caenorhabditis elegans set-25 Polyclonal antibody

Uniprot No.

G5EEU2

Target Names

set-25

Alternative Names

set-25 antibody; Y43F4B.3 antibody; Histone-lysine N-methyltransferase set-25 antibody; EC 2.1.1.- antibody; Histone H3-K9 methyltransferase set-25 antibody

Raised in

Rabbit

Species Reactivity

Caenorhabditis elegans

Immunogen

Recombinant Caenorhabditis elegans set-25 protein

Immunogen Species

Caenorhabditis elegans

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using mono- and dimethylated H3 'Lys-9' as substrate. Acts redundantly with the methyltransferase met-2 to position chromosome arms at the nuclear lamina. Required for small-RNA-induced H3K9 methylation. Together with met-2, protects and stabilizes repeat-rich genomic regions by suppressing transcription-induced replication stress through methylation of H3K9.

Gene References into Functions

Study shows that MET-2, a SETDB1 homolog, deposits mono- and dimethyl groups at H3K9, whereas SET-25, a previously uncharacterized histone methyltransferases, trimethylates the same residue. SET-25 colocalizes with peripheral heterochromatin in an H3K9me3-dependent fashion, thus becoming sequestered at the nuclear periphery by the product of its own methylation reaction. PMID: 22939621

Subcellular Location

Nucleus. Chromosome. Nucleus lamina.

Protein Families

Class V-like SAM-binding methyltransferase superfamily, Histone-lysine methyltransferase family

Database Links

KEGG: cel:CELE_Y43F4B.3

STRING: 6239.Y43F4B.3

UniGene: Cel.9798

Promotions

Email: [email protected]
Distributors Worldwide

Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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