SF3A1 Antibody

Code CSB-PA613594XA01HU
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) SF3A1 Polyclonal antibody
Uniprot No.
Target Names
SF3A1
Alternative Names
Pre mRNA processing 21 antibody; Pre mRNA splicing factor SF3a antibody; PRP21 antibody; PRPF21 antibody; SAP 114 antibody; SAP114 antibody; sf3a1 antibody; SF3A1_HUMAN antibody; SF3a120 antibody; Spliceosome associated protein 114 antibody; Spliceosome-associated protein 114 antibody; Splicing factor 3 subunit 1 antibody; Splicing factor 3a subunit 1 120kDa antibody; Splicing factor 3A subunit 1 antibody
Raised in
Rabbit
Species Reactivity
Homo sapiens (Human)
Immunogen
Recombinant Homo sapiens (Human) SF3A1 protein
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Involved in pre-mRNA splicing as a component of the splicing factor SF3A complex that contributes to the assembly of the 17S U2 snRNP, and the subsequent assembly of the pre-spliceosome 'E' complex and the pre-catalytic spliceosome 'A' complex. Involved in pre-mRNA splicing as a component of pre-catalytic spliceosome 'B' complexes.
Gene References into Functions
  1. Polymorphisms in SF3A1 gene is associated with pancreatic cancer. PMID: 26498691
  2. SF3A1 polymorphisms are not associated with Colorectal Cancer Risk. PMID: 26079486
  3. the SF3A mRNA splicing complex controls production of a negative regulator of TLR signaling that limits the extent of innate immune activation. PMID: 24204290
  4. show that U1-SL4 interacts with the SF3A1 protein of the U2 snRNP PMID: 25403181
  5. SF3a60, 66, and 120, but not SF1, are essential for pre-mRNA splicing PMID: 15647371

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Subcellular Location
Nucleus. Nucleus speckle.
Tissue Specificity
Ubiquitously expressed.
Database Links

HGNC: 10765

OMIM: 605595

KEGG: hsa:10291

STRING: 9606.ENSP00000215793

UniGene: Hs.406277

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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