sgg Antibody

1. Our findings demonstrated that lovastatin restored LRRK2-G2019S neurite degeneration by augmenting Akt/NRF2 pathway and inhibiting downstream GSK3b activity, which decreased phospho-tau levels. We suggested that lovastatin is a potential disease-modifying agent for LRRK2-G2019S parkinsonism. PMID: 26931464
2. Mitochondrial function leads to extensive glycogen accumulation late in oogenesis and is required for the developmental competence of the oocyte. Decreased insulin signaling initiates ETC remodeling and mitochondrial respiratory quiescence through glycogen synthase kinase 3 (GSK3). PMID: 26824655
3. Drosophila-based findings highlight an apical role for Hyd and Sgg in initiating Hedgehog signalling, which could also be evolutionarily conserved in mammals PMID: 26334301
4. Results show that downregulation of GSK3 promotes synapse formation in Drosophila neurons. However in rats hippocampal neurons, GSK3 inhibition yields to decrease of synapses in young neurons culture and the opposite in aged culture. PMID: 25764078
5. upregulation of Nebula/DSCR1 is neuroprotective in the presence of APP upregulation and provides evidence for calcineurin inhibition as a novel target for therapeutic intervention in preventing axonal transport impairments associated with AD PMID: 24086147
6. The Par-1/GSK-3/Slimb pathway plays important roles in limiting the amount of pole plasm posteriorly and in degrading any mislocalized Oskar that results from leaky translational repression. PMID: 23948254
7. GSK-3 is required for biderectional axonal transport. PMID: 23279138
8. findings suggest a mechanism in which Shaggy/GSK-3beta activates calcineurin through Sarah phosphorylation on egg activation in Drosophila PMID: 22421435
9. roles for the kinases GSK3 and aPKC in cellular alignment, asymmetric protein distribution, and adhesion during the development of this polarized tissue PMID: 21483653
10. Insulin induces Myc protein accumulation in Drosophila S2 cells, which correlates with a decrease in the activity of glycogen synthase kinase 3-beta (GSK3beta ) a kinase that is responsible for Myc protein degradation. PMID: 21951762
11. Wg signaling via Zw3 and mad restricts self-renewal of sensory organ precursor cells PMID: 21868604
12. The kinase Sgg modulates temporal development of macrochaetes in Drosophila by phosphorylation of Scute and Pannier. PMID: 22159580
13. GSK3 phosphorylation of Mad inhibits both BMP and Wg signaling. PMID: 21990430
14. Perturbation of the Akt/Gsk3-beta signalling pathway is common to Drosophila expressing expanded untranslated CAG, CUG and AUUCU repeat RNAs. PMID: 21518731
15. P188 affects stress-related p38 signaling, apoptosis-related GSK3, and inflammation-related IL-6 signaling. PMID: 20736797
16. Tau phosphorylation by Sgg at Thr212/Ser214 is important for Gly2019Ser to cause dendrite degeneration, which can be blocked by dominant-negative Sgg. PMID: 20881132
17. The Drosophila homolog of glycogen synthase kinase-3 (GSK-3)beta, Shaggy, is required for ethanol-induced apoptosis. PMID: 19923438
18. GSK3beta affects apical-basal polarity and cell-cell adhesion by regulating aPKC levels. PMID: 19422025
19. Sgg/GSK3 acts in conjunction with PKA to cause hyperphosphorylation of Ci, which targets it for proteolytic processing, and that Hh opposes Ci proteolysis by promoting its dephosphorylation. PMID: 11912487
20. Co-expression of human tau and constitutively active glycogen-synthase kinase-3beta (GSK-3beta) enhances and two GSK-3beta inhibitors, lithium and AR-A014418, reverse both the axon transport and locomotor phenotypes. PMID: 14993907
21. Expression of Shaggy (Sgg) in motoneurons controls neuromuscular junction growth. PMID: 15269269
22. Shaggy (Sgg)46 protein is cleaved by the Dark-dependent caspase; cleavage converts it to an active kinase, which contributes to the formation of neural precursor (sensory organ precursor (SOP)) cells PMID: 16222340
23. at least one GSK3beta phosphorylation site of MAP1B is conserved in Futsch and that this site can be phosphorylated by GSK3beta and its Drosophila homologue, Shaggy/Zeste-white 3 PMID: 16949836
24. shaggy functions in different neuronal circuits to regulate behavioral plasticity to an olfactory startle and circadian rhythmicity PMID: 17360579
25. shaggy, negatively influences AP-1-dependent synaptic growth, by modulating the Jun-N-terminal kinase pathway, and also regulates presynaptic neurotransmitter release at the larval neuromuscular junction. PMID: 18832361
26. Tau mutant resistant to phosphorylation by GSK-3beta/Shaggy retained substantial toxicity. PMID: 18930955
27. Zw3 plays a role in the maintenance of the mitotic spindle. PMID: 19029800
28. Gsk-3beta is a key sensor involved in neural circuit integrity, maintaining axon stability through neural activity and the Wnt pathway PMID: 19304886
29. Mutation of ck1alpha or -epsilon or sgg/gsk3beta in wing imaginal discs results in the accumulation of dMyc protein, suggesting a physiological role for these kinases in vivo. PMID: 19364825
30. inhibition of the serine-threonine kinase GSK-3beta completely suppresses the active zone development in Neuromuscular Junction of Drosophila. PMID: 19759297

Show More

Hide All

KEGG: dme:Dmel_CG2621

STRING: 7227.FBpp0304140

UniGene: Dm.7795