SGT2 Antibody

Code CSB-PA614180XA01SVG
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Product Details

Full Product Name
Rabbit anti-Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) SGT2 Polyclonal antibody
Uniprot No.
Target Names
SGT2
Alternative Names
SGT2 antibody; YOR007C antibody; UNF346 antibody; Small glutamine-rich tetratricopeptide repeat-containing protein 2 antibody; SGT/UBP antibody; Viral protein U-binding protein antibody
Raised in
Rabbit
Species Reactivity
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Immunogen
Recombinant Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) SGT2 protein
Immunogen Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Co-chaperone that binds to the molecular chaperone Hsp70 (SSA1 and SSA2). Regulates Hsp70 ATPase activity. Required for recovery from heat shock.
Gene References into Functions
  1. Report demonstrated that Ybr137wp and the Sgt2 TPR domain interact directly. PMID: 25288638
  2. SGTA(Sgt2) associates with and specifically regulates the androgen, glucocorticoid, and progesterone receptors and has no effect on the mineralocorticoid and estrogen receptors in both yeast and mammalian cell-based reporter assays. PMID: 24753260
  3. The crystal structure of Sgt2 dimerization domain complexed with the Get5 Ubl domain (Sgt2N-Get5Ubl) is reported. PMID: 24100326
  4. Sgt2 increases the ability of excess Ssa to counteract [PSI(+)] curing by excess Hsp104. One region of Sgt2 interacts both with the prion domain of Sup35 and with tail-anchored proteins. PMID: 23045389
  5. S. cerevisiae sgt2Delta cells show partial defects in TA protein sorting. PMID: 21619481

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Subcellular Location
Cytoplasm.
Protein Families
SGT family
Database Links

KEGG: sce:YOR007C

STRING: 4932.YOR007C

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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