unc-57 Antibody

Code CSB-PA913818XA01CXY
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Product Details

Full Product Name
Rabbit anti-Caenorhabditis elegans unc-57 Polyclonal antibody
Uniprot No.
Target Names
unc-57
Alternative Names
unc-57 antibody; T04D1.3 antibody; Endophilin-A homolog antibody; Endophilin-1 homolog antibody; Uncoordinated protein 57 antibody
Raised in
Rabbit
Species Reactivity
Caenorhabditis elegans
Immunogen
Recombinant Caenorhabditis elegans unc-57 protein
Immunogen Species
Caenorhabditis elegans
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Involved in synaptic vesicle (SV) recycling in neurons probably by regulating clathrin-mediated endocytosis. By controlling SV endocytosis, regulates the rate of excitatory postsynaptic currents (EPSCs) at neuromuscular junctions and thus locomotion. In a similar manner, involved in necrotic neuronal cell death induced by abnormal hyperactivation of ion channels. Plays a minor role in responses to mechanical stimuli. Plays a minor role in unc-26/synaptojanin localization to synapses.
Gene References into Functions
  1. Study shows that the membrane-bending activity is essential for unc-57 endophilin's function and that endophilin undergoes an association-dissociation cycle with SVs that parallels the cycle of exo- and endocytosis. PMID: 21029864
Subcellular Location
Cell junction, synapse. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle. Membrane; Peripheral membrane protein.
Protein Families
Endophilin family
Tissue Specificity
Expressed in neurons and posterior intestine.
Database Links

KEGG: cel:CELE_T04D1.3

STRING: 6239.T04D1.3d

UniGene: Cel.16827

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