SIM Antibody

Datasheet

Code	CSB-PA847167XA01DOA
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Product Details
Customer Reviews and Q&A
Target Background

Product Details

Full Product Name

Rabbit anti-Arabidopsis thaliana (Mouse-ear cress) SIM Polyclonal antibody

Uniprot No.

Q9LZ78

Target Names

SIM

Alternative Names

SIM antibody; At5g04470 antibody; T32M21.70 antibody; Cyclin-dependent protein kinase inhibitor SIM antibody; Protein SIAMESE antibody

Raised in

Rabbit

Species Reactivity

Arabidopsis thaliana

Immunogen

Recombinant Arabidopsis thaliana SIM protein

Immunogen Species

Arabidopsis thaliana (Mouse-ear cress)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

■ Customer Reviews

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Target Background

Function

Cyclin-dependent protein kinase (CDK) inhibitor that functions as a repressor of mitosis in the endoreduplication cell cycle. Inhibits the kinase activity of CYCD3-1/CDKA-1, CYCD2-1/CDKA-1 and CYCB1-1/CDKB1-1 complexes in a dose dependent manner. Cooperates with SMR1 and SMR2 to promote endoreplication during leaf development. Required for normal trichome endoreplicating cell cycles. Positive regulator of effector-triggered immunity (ETI).

Gene References into Functions

SIM role in regulating cell-cycle progression and innate immunity PMID: 26561564
The analysis of genes preferentially expressed in gl3-sst sim double mutant led to the identification of four additional genes required for normal trichome development. PMID: 19626137
SIM encodes a plant-specific CDK (Cyclin dependent kinase) inhibitor with a key function in the mitosis-to-endoreplication transition. [SIAMESE] [SIM] PMID: 17098811
A novel interaction between mutant alleles of two genes, gl3-sst derived from GL3, and SIM exhibits mounds of cells derived from the proliferation of single trichome precursors. [SIAMESE] [SIM] PMID: 17764505

Subcellular Location

Nucleus.

Tissue Specificity

Expressed in the shoot apical meristem, leaf primordia and the elongation zone of the root.

Database Links

KEGG: ath:AT5G04470

STRING: 3702.AT5G04470.1

UniGene: At.25536

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