sim Antibody

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Code	CSB-PA356603XA01DLU
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Product Details

Full Product Name

Rabbit anti-Drosophila melanogaster (Fruit fly) sim Polyclonal antibody

Uniprot No.

P05709

Target Names

sim

Alternative Names

sim antibody; CG7771 antibody; Protein single-minded antibody

Raised in

Rabbit

Species Reactivity

Drosophila melanogaster (Fruit fly)

Immunogen

Recombinant Drosophila melanogaster (Fruit fly) sim protein

Immunogen Species

Drosophila melanogaster (Fruit fly)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

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Target Background

Function

Transcription factor that functions as a master developmental regulator controlling midline development of the ventral nerve cord. Required to correctly specify the formation of the central brain complex, which controls walking behavior. Also required for correct patterning of the embryonic genital disk and anal pad anlage. Plays a role in synapse development.

Gene References into Functions

Single-minded directly regulates midline primordium-expressed genes, but in some cases plays a primary role in directing target gene midline expression, and in others provides midline specificity to cell signaling inputs. PMID: 24854999
the number of Sim-Tgo-binding sites is decisive in determining the timing of gene expression in the developing ventral midline. PMID: 23701883
Single-minded collaborates with Zelda to regulate an evolutionarily dynamic CNS midline cell enhancer PMID: 22537497
Novel behavioral and developmental defects associated with gene expression PMID: 12221007
acts on identified reg seq of the roughest gene PMID: 16096801
Different portions of the embryonic gut require sim functions at different times for normal left-right asymmetry. PMID: 17241775

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Subcellular Location

Nucleus.

Tissue Specificity

Embryonic nerve cord.

Database Links

KEGG: dme:Dmel_CG7771

STRING: 7227.FBpp0082178

UniGene: Dm.4557

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sim Antibody

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