sir-2.1 Antibody

1. SIRT1 plays essential roles in cell survival, inflammation, energy metabolism, and aging. PMID: 25976661
2. The authors show that the mating circuits' functional durability depends on the metabolic regulator SIR-2.1, a NAD(+)-dependent histone deacetylase. PMID: 24755287
3. Sir-2.1; dnj-14 double mutants showed full lifespan rescue by resveratrol. PMID: 24947438
4. C. elegans produces specific small molecules to control adult lifespan in a SIR-2.1-dependent manner. PMID: 23509272
5. Overexpression of SIR2.1 protects neurons from mutant huntingtin toxicity. PMID: 22956852
6. caloric restriction increases the ability of heat shock to preserve movement in a polyglutamine toxicity neurodegenerative disease model and that this effect is dependent on sir2.1. PMID: 22778258
7. calorie restriction affords, an sir-2.1 mediated, protection against the dopaminergic neurodegeneration, that might have implications for neurodegenerative Parkinson's disease. PMID: 21889494
8. data suggest that SIRT1 activators have therapeutic potential in prion diseases to protect neurons from the detrimental effects of misfolded PrP conformers on intracellular signaling and homeostasis PMID: 20392961
9. activation of Sirtuin-1 (by the pharmacological agent resveratrol and/or genetic means) per se ignites autophagy, and that Sirtuin-1 is required for the autophagic response to nutrient deprivation PMID: 20023410
10. SIR-2.1 and 14-3-3 act in parallel to the insulin-like pathway to activate DAF-16 and extend life span. PMID: 16777605
11. Dietary restriction (DR) can robustly extend the lifespan of worms lacking the AAK2 or SIR-2.1, identifying universal regulators of DR mediated longevity PMID: 19229346
12. Data indicate that SIR-2.1 and HIS-24 contribute to the propagation of a specialized chromatin state at the subtelomeric regions and elsewhere in the genome. PMID: 19380489

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KEGG: cel:CELE_R11A8.4

STRING: 6239.R11A8.4a

UniGene: Cel.12479