Sirt1 Antibody

1. Sir2 in the mushroom bodies promotes short-term ethanol-induced behavioral plasticity by allowing changes in the expression of presynaptic molecules. PMID: 27170122
2. The role of Sirt1 in Notch signalling is, therefore, more complex than previously recognized, and its diverse effects may be explained by a plethora of Sirt1 substrates involved in the regulation of Notch signalling. PMID: 27623778
3. A lowered gene dosage of Sir2, in mutant heterozygotes, can extend normal longevity and greatly augment survivorship during amino-acid starvation in Drosophila. PMID: 27074822
4. Drosophila HNF4 mutants display diabetic phenotypes similar to those of sir2 mutants, and protein levels for dHNF4 are reduced in sir2 mutant animals. Sir2 exerts these effects by deacetylating and stabilizing dHNF4 through protein interactions. PMID: 27058248
5. Low oxygen partial pressure of highly resistant Drosophila significantly reduces the time of restitution and increases the expression of Sir2 and CG14740 genes. PMID: 25335240
6. Using two transgenic dSir2 lines that were reported not to extend life span, we show significant life span extension when dSir2 expression is induced between 2 and 5-fold. PMID: 24036492
7. This study provides additional independent evidence for the concept of Sir2 as a longevity gene and as a promising pharmacological target to cure age-related diseases. PMID: 23765091
8. dSir2 in the adult fat body, but not in muscles, regulates life span in a diet-dependent manner. PMID: 23246004
9. Muscle dSir2 regulates mitochondrial functions and energy homeostasis autonomously and mimics the nonautonomous effects of fat body dSir2. PMID: 23129806
10. Polo-mediated phosphorylation of Maelstrom may be a mechanism that controls oocyte determination by inactivating the pachytene checkpoint via the repression of Sir2 in Drosophila ovaries. PMID: 23136393
11. Report delineates the functions of dSir2 in the fatbody and muscles with systemic consequences on fat metabolism and insulin signaling. PMID: 22411915
12. tetrahydrocurcumin may regulate the aging process via an evolutionarily conserved signaling pathway that includes both foxo and Sir2. PMID: 22156377
13. negative findings do not rule out a role for sirtuins in determination of metazoan lifespan, but they do cast doubt on the robustness of the previously reported effects of sirtuins on lifespan in C. elegans and Drosophila PMID: 21938067
14. Evidence in Drosophila implicates Sir2 in at least some of the beneficial effects of caloric restriction PMID: 20728527
15. These findings point to a Sir2-mediated pathway that activates a catabolic response to amino-acid starvation irrespective of the sugar content of the diet. PMID: 21085633
16. Dmp53 is a down stream target of dSir2 enzymatic activity and mediates some aspects of the life span extending effects of caloric restriction. PMID: 19851477
17. In Drosophila, spontaneous physical activity closely mimics life span in its dependence on Sir2. PMID: 20157536
18. Sir2 interacts with members of the Hairy/Deadpan/E(Spl) family of bHLH euchromatic repressors, key regulators of Drosophila development. Sir2 plays a role in both euchromatic repression and heterochromatic silencing. PMID: 12086602
19. modifies position-effect variegation but does not affect life span PMID: 12524341
20. role in histone deacetylation generates a transcriptionally repressed nucleoprotein complex PMID: 12571358
21. dsir2 is nonessential and its loss alone has only very subtle effects PMID: 12663533
22. Hairy cofactor recruitment is context-dependent: while Groucho is associated with a minority of Hairy targets, the majority of Hairy targets are associated with the presence of a combination of dCtBP and dSir2 PMID: 15252443
23. Lifespan extension is dependent on functional Sir2, and is not observed when nutrients are restricted PMID: 15254550
24. SIR2 is involved in the epigenetic inheritance of silent chromatin states mediated by the Drosophila Polycomb group proteins and is physically associated with a complex containing the E(Z) histone methyltransferase. PMID: 15498488
25. an increase in Drosophila Sir2 (dSir2) extends life span, whereas a decrease in dSir2 blocks the life-span-extending effect of calorie reduction or rpd3 mutations PMID: 15520384
26. Extends longevity by overexpression. PMID: 15935564
27. Sir2 normally participates in the regulation of cell survival and death in Drosophila. PMID: 18562277
28. Huntington's disease in Drosophila model is most readily impacted by inhibition of Rpd3 and Sir2 either individually or in combination. PMID: 18762557

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KEGG: dme:Dmel_CG5216

STRING: 7227.FBpp0080015

UniGene: Dm.415