SIR4 Antibody

1. the silencing factor Sir4, NE-associated Esc1, the SUMO E3 ligase Siz2, and the nuclear pore complex (NPC) protein Nup170-physically and functionally interact with one another and a subset of NPC components (nucleoporins or Nups). PMID: 28883038
2. data support a model whereby the demethylation of histone H3 K79 and changes in Sir4 abundance and availability define two rate-limiting steps that regulate de novo assembly of heterochromatin PMID: 26587833
3. The authors show that Sir4 - a previously identified Ku-binding protein that is a component of telomeric silent chromatin - is required for Ku-mediated telomere lengthening and telomerase recruitment. PMID: 26218225
4. These results demonstrate that the SCF(Dia2) complex is involved in transcriptional silencing, ubiquitylates Sir4, and regulates transcriptional silencing during the cell cycle. PMID: 22844255
5. Sir4 N-terminus plays two roles in SIR-mediated silencing: it contributes to epigenetic repression by stabilizing the SIR-mediated protection of linker DNA; and, as a target of phosphorylation, it can destabilize silencing in a regulated manner. PMID: 22654676
6. Elongator mutants influence telomeric gene silencing by impairing efficient expression of SIR4. PMID: 21912530
7. Sir4(PAD)-mediated tethering requires either the Ku complex or Esc1, an acidic protein that is localized to the inner face of the nuclear envelope even in the absence of Ku, Sir4 or Nup133 PMID: 15014445
8. Results suggest that the telomeric component Sir4p interact genetically and physically with GSP1 and together they regulate proper telomeric function in yeast. PMID: 16956377

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KEGG: sce:YDR227W

STRING: 4932.YDR227W