Product Details

Full Product Name

Rabbit anti-Caenorhabditis elegans slo-1 Polyclonal antibody

Uniprot No.

Q95V25

Target Names

slo-1

Alternative Names

slo-1 antibody; Y51A2D.19 antibody; Calcium-activated potassium channel slo-1 antibody; BK channel antibody; Maxi K channel antibody; MaxiK antibody; Slo homolog antibody; Slowpoke protein 1 antibody

Raised in

Rabbit

Species Reactivity

Caenorhabditis elegans

Immunogen

Recombinant Caenorhabditis elegans slo-1 protein

Immunogen Species

Caenorhabditis elegans

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Target Background

Function

Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Essential for the regulation of neurotransmitter release at synapses.

Gene References into Functions

Enhanced SLO-1 function, via gain-of-function mutation or overexpression, dramatically reduced behavioral impairment during ethanol withdrawal. PMID: 28546434
This study demonistrated that the T352I mutation selectively disrupts ethanol modulation of the BK channel. PMID: 25031399
This study shows cellular and whole organismal behavioral responses to ethanol in C. elegans that directly equate to intoxicating through to supralethal blood alcohol concentrations in humans. PMID: 23882127
slo-1 mutants failed to exhibit ethanol interference with gustatory plasticity in Caenorhabditis elegans PMID: 21889959
proper coordination of intragenic alternative splicing is essential for normal physiology of slo-1 in vivo PMID: 22084100
These observations revealed novel functions of the BK channel in regulating muscle Ca(2+) transients PMID: 22131396
Our experiments confirmed that SLO-1 channels mediate the activity of the new anthelmintic drug emodepside. PMID: 21490955
dystrophin-associated protein complex modulates muscle excitability by localizing the SLO-1 channel to calcium-rich regions of C. elegans muscle. PMID: 20019812
Slo-1 mutants are highly resistant to ethanol in two behavioral assays. Numerous loss-of-function slo-1 alleles emerged from our screens, indicating that slo-1 has a central role in ethanol responses. PMID: 14675531

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Subcellular Location

Cell membrane; Multi-pass membrane protein. Cell junction, synapse.

Protein Families

Potassium channel family, Calcium-activated (TC 1.A.1.3) subfamily, Slo sub-subfamily

Tissue Specificity

Expressed in synaptic regions of the nervous system including in both the nerve ring and nerve cords, as well as in the body-wall and vulval muscle.

Database Links

STRING: 6239.Y51A2D.19a

UniGene: Cel.7073

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slo-1 Antibody

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