SMC5 Antibody

Datasheet
Code CSB-PA804506XA01MO
Product Type Polyclonal Antibody
Uniprot No. Q8CG46
Delivery Make-to-order
Immunogen Recombinant Mus musculus (Mouse) SMC5 protein
Raised in Rabbit
Species Reactivity Mus musculus (Mouse)
Tested Applications ELISA, WB (ensure identification of antigen)
Form Liquid
Conjugate Non-conjugate
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method Protein A/G
Isotype IgG
Clonality Polyclonal
Alias Structural maintenance of chromosomes protein 5 (SMC protein 5) (SMC-5) (mSMC5) (Protein expressed in male leptotene and zygotene spermatocytes 453) (MLZ-453) Smc5 Kiaa0594 Smc5l1
Immunogen Species Mus musculus (Mouse)
Protocols ELISA Protocol
Gene Names Smc5
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components. Required for sister chromatid cohesion during prometaphase and mitotic progression; the function seems to be independent of SMC6 (By similarity).
Subcellular Location Nucleus, Chromosome, Nucleus, PML body, Chromosome, telomere
Protein Families SMC family, SMC5 subfamily
Tissue Specificity Expressed in testis but not ovary.
Database Links

KEGG: mmu:226026

STRING: 10090.ENSMUSP00000084837

UniGene: Mm.23267

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