smn1 Antibody

1. we established that the additional supply of Smn protein in motoneurons is necessary for proper axonogenesis in a cell-autonomous manner PMID: 27273160
2. In motor neurons, smn1 interacts with the RNA binding protein, HuD and regulates motoneuron development and function. PMID: 29061699
3. our finding that elevation of Pgk1 levels or activity, via injection of Pgk1 mRNA or treatment with terazosin respectively, robustly ameliorated MN pathology in smn morphant zebrafish provides an initial demonstration that these pathways are amenable to therapeutic intervention. PMID: 28426667
4. Reduction of Gemin2, unlike reduction of SMN, in zebrafish embryos does not directly cause motor axon outgrowth defects. PMID: 18000835
5. SMN deficiency affects splicing and abundance of nrxn2a. This may explain the pre-synaptic defects at neuromuscular endplates in SMA pathophysiology. PMID: 24218366
6. SMN is needed early in development of motoneuron dendrites and axons to develop normally and that this is essential for proper connectivity and movement. PMID: 23459934
7. These results show that survival motor neuron functions in motor axon development and suggest that these early developmental defects may lead to subsequent motoneuron loss. PMID: 12952942
8. Survival motor neuron has a novel function in motor neurons independent of small nuclear ribonucleoprotein (snRNP) biosynthesis. PMID: 17065443
9. Since Gemin2 and SMN both function in snRNP biogenesis yet only SMN knockdown causes motor axon defects, these data are consistent with an additional role for SMN that is snRNP independent. PMID: 18000835
10. Smn mutants in zebrafish survive to larval stages and exhibit presynaptic neuromuscular junction defects. PMID: 19592581

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KEGG: dre:30432

STRING: 7955.ENSDARP00000017636

UniGene: Dr.75206