SNC1 Antibody

Code CSB-PA517811XA01DOA
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Product Details

Full Product Name
Rabbit anti-Arabidopsis thaliana (Mouse-ear cress) SNC1 Polyclonal antibody
Uniprot No.
Target Names
SNC1
Alternative Names
SNC1 antibody; BAL antibody; At4g16890 antibody; dl4475c antibody; FCAALL.51 antibody; Protein SUPPRESSOR OF npr1-1 antibody; CONSTITUTIVE 1 antibody; AtSNC1 antibody; Disease resistance RPP5-like protein antibody; Probable NAD(+) hydrolase SNC1 antibody; EC 3.2.2.6 antibody
Raised in
Rabbit
Species Reactivity
Arabidopsis thaliana
Immunogen
Recombinant Arabidopsis thaliana SNC1 protein
Immunogen Species
Arabidopsis thaliana (Mouse-ear cress)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Disease resistance protein of the TIR-NB-LRR-type. Part of the RPP5 locus that contains a cluster of several paralogous disease resistance (R) genes. Resistance proteins guard the plant against pathogens that contain an appropriate avirulence protein via an indirect interaction with this avirulence protein. That triggers a defense system including the hypersensitive response, which restricts the pathogen growth. Probably acts as a NAD(+) hydrolase (NADase): in response to activation, catalyzes cleavage of NAD(+) into ADP-D-ribose (ADPR) and nicotinamide; NAD(+) cleavage triggering a defense system that promotes cell death. Expression regulated by MOS1 at chromatin level. Nuclear localization of SNC1 is essential for its activity. ABA deficiency can rescue high-temperature inhibition of SNC1-mediated defense responses.
Gene References into Functions
  1. SNC1 is a major mediator of defense response modulated by SIZ1 and that SNC1 is a crucial target for fine-tuning plant defense responses. PMID: 28409535
  2. This study provides structural platform to investigate AtSNC1-TIR mediated signaling pathway of plant immune responses. PMID: 27818198
  3. MUSE13 and MUSE14 contribute to the turnover of nucleotide-binding domain and leucine-rich repeat-containing (NLR) immune receptors SNC1 and RPS2. PMID: 26867179
  4. SNC1 protein accumulated in taf15b mutant, suggesting that TAF15b contributes to SNC1 homeostasis through posttranscriptional mechanisms. PMID: 26713351
  5. abnormal pavement cell morphogenesis in cpr1 is accompanying with the aberrant arrangement of cytoskeleton. PMID: 26193674
  6. SNC1 exhibits a few distinct N-terminal isoforms generated through alternative initiation and N-terminal acetylation. PMID: 25966763
  7. nuclear SNC1 is necessary for rapid activation of downstream defense responses of plant immunity PMID: 25237053
  8. MOS2 contributes to proper splicing of SNC1 transcript, redundantly with MOS2H. PMID: 23803746
  9. Abscisic acid deficiency enhances disease resistance mediated by SNC1 at high temperature. PMID: 22454454
  10. Study report the gene expression pattern and subcellular localization of MOS1. In addition, study analyzes and discusses the roles of DNA and histone methylation in mos1-mediated suppression of SNC1 expression. PMID: 21350329
  11. MODIFIER OF snc1, 1 (MOS1) regulates the expression of SUPPRESSOR OF npr1-1, CONSTITUTIVE1 (SNC1), which encodes a Toll/interleukin receptor-nucleotide binding site-leucine-rich repeat type of R protein in Arabidopsis PMID: 20439546
  12. overexpression of TPR1 constitutively activates SNC1-mediated immune responses. PMID: 20647385
  13. We isolated Arabidopsis mutants with point mutation in SNC1 that retain disease resistance at a higher growth temperature PMID: 20368979
  14. We propose that the high degree of variation in SNC1-related sequences among Arabidopsis natural accessions follows the two-step mechanism observed in the bal variant: gene duplication followed by hypermutation. PMID: 19797048
  15. One mutant that suppresses snc1-mediated constitutive resistance is modifier of snc1 5 (mos5), which carries a 15-bp deletion in UBA1. PMID: 17217463
  16. The regulation of SNC1 possibly exemplifies a universally complex control of R genes to ensure a repression of R activation under nonstress conditions and a robust activation of defense responses once the R gene is induced. PMID: 17977156

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Subcellular Location
Cytoplasm. Microsome. Nucleus.
Protein Families
Disease resistance NB-LRR family
Tissue Specificity
Expressed in guard cells and epidermal cells, but not detected in mesophyll cells.
Database Links

KEGG: ath:AT4G16890

STRING: 3702.AT4G16890.1

UniGene: At.43451

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