sNPF Antibody

Code CSB-PA894700XA01DLU
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Product Details

Full Product Name
Rabbit anti-Drosophila melanogaster (Fruit fly) sNPF Polyclonal antibody
Uniprot No.
Target Names
sNPF
Alternative Names
sNPF antibody; CG13968 antibody; Short neuropeptide F [Cleaved into: sNPF-associated peptide antibody; sNPF-AP); sNPF peptide 2 antibody; sNPF-2); sNPF peptide 3 antibody; sNPF-3); sNPF peptide 4 antibody; sNPF-4); RLRF peptide 1; RLRF peptide 2] antibody
Raised in
Rabbit
Species Reactivity
Drosophila melanogaster (Fruit fly)
Immunogen
Recombinant Drosophila melanogaster (Fruit fly) sNPF protein
Immunogen Species
Drosophila melanogaster (Fruit fly)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Plays a role in controlling food intake and regulating body size.
Gene References into Functions
  1. Light and the neuropeptides PDF and sNPF act dynamically at distinct hubs of the circadian neural circuit to produce multiple suppressive events that create the proper tempo and sequence of circadian pacemaker neuronal activities. PMID: 28552314
  2. Findings indicate that short neuropeptide F (sNPF) and corazonin (CRZ) co-released from a small set of neurons regulate insulin-producing cells (IPCs) stress resistance and metabolism. PMID: 22828865
  3. Loss of function of sNPF and sNPFR1 also elevated sleep. PMID: 23796436
  4. Here we show that a neuropeptide precursor gene encoding four types of short neuropeptide F (sNPF) is required in the Kenyon cells for appetitive olfactory memory. PMID: 23516298
  5. Different layers of the fan-shaped body sNPFR1 PMID: 22361394
  6. sNPF is expressed in the nervous systems to control food intake and regulate body size in Drosophila melanogaster PMID: 15385546
  7. Results show that Drosophila short neuropeptide F, an orthologue of mammalian neuropeptide Y, and sNPF receptor sNPFR1 regulate expression of insulin-like peptides. PMID: 18344986
  8. Data show Drosophila brain expressing short neuropeptide F transcript and short neuropeptide F peptide. Most of these PMID: 18803813
  9. We have demonstrated here that subsets of Drosophila lateral clock neurons are heterogeneous with respect to expression of neuroactive compounds, including ion transport peptide and short neuropeptide F PMID: 19565664
  10. These results indicate that sNPF1 and sNPF2 peptides processed from the sNPF precursor are sufficient for regulating body growth through the ERK-insulin pathway in Drosophila. PMID: 19619547

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Subcellular Location
Secreted.
Protein Families
NPY family
Tissue Specificity
Stage 17 embryos show expression in the two brain hemispheres (neural cells located in the dorsal posterior region), the connected ventral ganglion (pairs of neural cells along the ventral midline) and the peripheral nervous system (expressed in the anten
Database Links

KEGG: dme:Dmel_CG13968

STRING: 7227.FBpp0080859

UniGene: Dm.5706

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