so Antibody

Code CSB-PA632924XA01DLU
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Product Details

Full Product Name
Rabbit anti-Drosophila melanogaster (Fruit fly) so Polyclonal antibody
Uniprot No.
Target Names
so
Alternative Names
so antibody; CG11121 antibody; Protein sine oculis antibody
Raised in
Rabbit
Species Reactivity
Drosophila melanogaster (Fruit fly)
Immunogen
Recombinant Drosophila melanogaster (Fruit fly) so protein
Immunogen Species
Drosophila melanogaster (Fruit fly)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Required for visual system development. May transcriptionally regulate genes necessary for optic lobe invagination and Bolwig's nerve formation.
Gene References into Functions
  1. By removing gene function in differentiating cells, the study shows that so is dispensable for larval photoreceptor differentiation, but is required for differentiation during pupal development. PMID: 27257739
  2. mapping of So-enriched regions throughout the genome in third instar larval eye discs; study found 7,566 So-enriched regions, which map to approximately 5,952 genes, including previously characterized So targets in the eye PMID: 24586968
  3. atonal expression in Drosophila retinal progenitors involves redundant and synergistic contributions of Ey/Pax6 and So binding sites within two distant enhancers PMID: 24247006
  4. Loss of So in the eye disc caused ectopic antenna development in the eye. PMID: 22912416
  5. Data suggest that during early phases of eye development, So and Optix function, in part, to repress the transcription of non-retinal selector genes, thereby allowing induction of the retina to proceed. PMID: 22318629
  6. Results describe the roles of sine oculis and glass proteins in the development of the Drosophila corpus cardiacum. PMID: 15385159
  7. A novel dominant-negative mutation within the six domain of the conserved eye specification gene so inhibits eye development. PMID: 15704100
  8. genome-wide search and have thereby been able to identify eyeless as well as the signalling gene hedgehog as putative targets of so PMID: 15901665
  9. different cofactors likely mediate unique functions of Sine oculis and Optix during the development of the fly eye PMID: 15937930
  10. dominant mutant phenotype is primarily due to an alteration in binding properties of the Sine oculis protein during eye development PMID: 16125693
  11. Study shows that distinct cis-regulatory elements control atonal expression specifically in the eye and that the Retinal Determination factors Eyeless and Sine oculis function as direct regulators. PMID: 17108002
  12. expression of so on its own is sufficient to induce eye development within non-retinal tissues PMID: 17137572

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Subcellular Location
Nucleus.
Protein Families
SIX/Sine oculis homeobox family
Tissue Specificity
In developing embryos, expressed in the eye disk epithelium, bolwig's organ and the optic lobe primordium at areas of invagination. In adults, present in photoreceptor cells in the apical regions of the retina, and in optic lobes.
Database Links

KEGG: dme:Dmel_CG11121

STRING: 7227.FBpp0089177

UniGene: Dm.4727

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