SODM Antibody

Code CSB-PA679571XA01DLU
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Product Details

Full Product Name Rabbit anti-Drosophila melanogaster (Fruit fly) Sod2 Polyclonal antibody
Uniprot No. Q00637
Target Names Sod2
Alternative Names Sod2 antibody; CG8905 antibody; Superoxide dismutase [Mn] antibody; mitochondrial antibody; EC 1.15.1.1 antibody
Raised in Rabbit
Species Reactivity Drosophila melanogaster (Fruit fly)
Immunogen Recombinant Drosophila melanogaster (Fruit fly) SODM protein
Immunogen Species Drosophila melanogaster (Fruit fly)
Conjugate Non-conjugated
Clonality Polyclonal
Isotype IgG
Purification Method Protein A/G
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form Liquid
Tested Applications ELISA, WB (ensure identification of antigen)
Protocols ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables ① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee ① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time Made-to-order (14-16 weeks)

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Target Background

Function
(From Uniprot)
Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
Gene References into Functions
  1. Depletion of superoxide dismutases promotes muscular and neuronal ROS accumulation which may have a significant effect on age-dependent impairment of the Drosophila adults. PMID: 25801590
  2. Paraquat exposure, but not Sod2 knockdown, resulted in increased carbonylated protein relative abundance. PMID: 25091824
  3. The functional SOD1 and SOD2 genes knockout and their overexpression in neurons and glial tissue increase the sensitivity of Drosophila melanogaster to oxidative stress conditions. PMID: 26030970
  4. ocytes lacking maternal SOD2 protein develop into adults just like normal SOD2-containing oocytes suggesting that maternal SOD2-mediated protection against mitochondrial ROS is not essential for oocyte viability PMID: 21212740
  5. knockdown in the musculature has whole-organism consequences PMID: 19545620
  6. Muscles appear to be more sensitive to superoxide attack relative to the neurons and such overt phenotypes observed in SOD2-deficient animals can be directly attributed to the muscle. PMID: 19546321
  7. Overexpression of Cu,ZnSOD and MnSOD in transgenic Drosophila. PMID: 11912910
  8. Ablation of mitochondrial SOD2 through expression of a GAL4-regulated, inverted-repeat Sod2 RNA-interference causes increased endogenous oxidative stress, loss of respiratory chain & TCA cycle components,& early-onset mortality in young adults. PMID: 12456885
  9. Effects of overexpression of copper-zinc and manganese superoxide dismutases, catalase, and thioredoxin reductase genes on longevity. PMID: 12743125
  10. The chromosomal deficiency Df(2R)017 significantly up-regulated MnSOD mRNA by 1.7-fold. Deficiency in four other genomic intervals, Df(1)ct-J4, Df(2L)BSC4, Df(3L)66C-G28 and Df(3R)Scr, down-regulated MnSOD expression. PMID: 12934716
  11. SOD1 and SOD2 provide independent protection to compartment-specific protein iron-sulfur clusters against attack by superoxide generated under oxidative stress PMID: 12972424
  12. Disruption of the protective effects of SOD2 on mitochondria manifests as profound changes in behavioral and demographic aging as well as exacerbated age-related pathology in the nervous system. PMID: 18078670
  13. switching moribund SOD2-deficient adults from normoxia into hypoxia arrests premature mortality and endows the survivors with a near-normal life PMID: 18983909
  14. Data show that the decline of several functional measures of aging occurs, in an accelerated fashion, in Sod2 mutants. PMID: 19148770

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Subcellular Location Mitochondrion matrix.
Protein Families Iron/manganese superoxide dismutase family
Database Links

KEGG: dme:Dmel_CG8905

STRING: 7227.FBpp0086226

UniGene: Dm.4800

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