Sod2 Antibody

1. Depletion of superoxide dismutases promotes muscular and neuronal ROS accumulation which may have a significant effect on age-dependent impairment of the Drosophila adults. PMID: 25801590
2. Paraquat exposure, but not Sod2 knockdown, resulted in increased carbonylated protein relative abundance. PMID: 25091824
3. The functional SOD1 and SOD2 genes knockout and their overexpression in neurons and glial tissue increase the sensitivity of Drosophila melanogaster to oxidative stress conditions. PMID: 26030970
4. ocytes lacking maternal SOD2 protein develop into adults just like normal SOD2-containing oocytes suggesting that maternal SOD2-mediated protection against mitochondrial ROS is not essential for oocyte viability PMID: 21212740
5. knockdown in the musculature has whole-organism consequences PMID: 19545620
6. Muscles appear to be more sensitive to superoxide attack relative to the neurons and such overt phenotypes observed in SOD2-deficient animals can be directly attributed to the muscle. PMID: 19546321
7. Overexpression of Cu,ZnSOD and MnSOD in transgenic Drosophila. PMID: 11912910
8. Ablation of mitochondrial SOD2 through expression of a GAL4-regulated, inverted-repeat Sod2 RNA-interference causes increased endogenous oxidative stress, loss of respiratory chain & TCA cycle components,& early-onset mortality in young adults. PMID: 12456885
9. Effects of overexpression of copper-zinc and manganese superoxide dismutases, catalase, and thioredoxin reductase genes on longevity. PMID: 12743125
10. The chromosomal deficiency Df(2R)017 significantly up-regulated MnSOD mRNA by 1.7-fold. Deficiency in four other genomic intervals, Df(1)ct-J4, Df(2L)BSC4, Df(3L)66C-G28 and Df(3R)Scr, down-regulated MnSOD expression. PMID: 12934716
11. SOD1 and SOD2 provide independent protection to compartment-specific protein iron-sulfur clusters against attack by superoxide generated under oxidative stress PMID: 12972424
12. Disruption of the protective effects of SOD2 on mitochondria manifests as profound changes in behavioral and demographic aging as well as exacerbated age-related pathology in the nervous system. PMID: 18078670
13. switching moribund SOD2-deficient adults from normoxia into hypoxia arrests premature mortality and endows the survivors with a near-normal life PMID: 18983909
14. Data show that the decline of several functional measures of aging occurs, in an accelerated fashion, in Sod2 mutants. PMID: 19148770

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KEGG: dme:Dmel_CG8905

STRING: 7227.FBpp0086226

UniGene: Dm.4800