sorf-1 Antibody

Code CSB-PA554805XA01CXY
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Product Details

Full Product Name
Rabbit anti-Caenorhabditis elegans sorf-1 Polyclonal antibody
Uniprot No.
Target Names
sorf-1
Alternative Names
sorf-1 antibody; ZK563.5 antibody; Suppressor of organelle fusion 1 antibody
Raised in
Rabbit
Species Reactivity
Caenorhabditis elegans
Immunogen
Recombinant Caenorhabditis elegans sorf-1 protein
Immunogen Species
Caenorhabditis elegans
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Together with sorf-2 negatively regulates the levels of phosphatidylinositol 3-phosphate (PtdIns3P) to enable the conversion of early endosomes to late endosomes. Binds to sorf-2 and the sorf-1-sorf-2 complex likely acts through bec-1, a non-catalytic subunit of phosphatidylinositol 3-kinase (PI3K), to suppress PI3K activity, thereby negatively regulating endosomal PtdIns3P levels.
Gene References into Functions
  1. SORF-1 and SORF-2 are essential for appropriate maintenance of PtdIns3P levels in early-to-late endosome conversion PMID: 26783301
Subcellular Location
Early endosome. Late endosome. Cytoplasm.
Protein Families
WD repeat WDR91 family
Database Links

KEGG: cel:CELE_ZK563.5

UniGene: Cel.9218

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