soxR Antibody

Code CSB-PA364851XA01ENV
Size Enquire
Have Questions? Leave a Message or Start an on-line Chat

Product Details

Full Product Name
Rabbit anti-Escherichia coli (strain K12) soxR Polyclonal antibody
Uniprot No.
Target Names
soxR
Alternative Names
soxR antibody; marC antibody; b4063 antibody; JW4024 antibody; Redox-sensitive transcriptional activator SoxR antibody
Raised in
Rabbit
Species Reactivity
Escherichia coli (strain K12)
Immunogen
Recombinant Escherichia coli (strain K12) soxR protein
Immunogen Species
Escherichia coli (strain K12)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

Customer Reviews and Q&A

 Customer Reviews

There are currently no reviews for this product.

Submit a Review here

Target Background

Function
Activates the transcription of the soxS gene which itself controls the superoxide response regulon. SoxR contains a 2Fe-2S iron-sulfur cluster that may act as a redox sensor system that recognizes superoxide. The variable redox state of the Fe-S cluster is employed in vivo to modulate the transcriptional activity of SoxR in response to specific types of oxidative stress. Upon reduction of 2Fe-2S cluster, SoxR reversibly loses its transcriptional activity, but retains its DNA binding affinity.
Gene References into Functions
  1. Data indicate reaction of nitric oxide with transcription factor SoxR by pulse radiolysis. PMID: 24747116
  2. This review focuses on the mechanisms by which SoxR proteins respond to oxidative stress. PMID: 24332474
  3. study compared responsiveness of SoxRs from Streptomyces coelicolor, Pseudomonas aeruginosa and E. coli towards redox-active compounds; ScSoxR is the most limited in the range of chemicals to which it responds and has highest reduction potential; both kinetic and redox potential factors determine range of effective chemicals PMID: 24112649
  4. Analysis of apo-SoxR binding determines that the effect of apo-SoxR on DNA triple-crossover molecules (TX) in the cohesive tract of a DNA-based mechanical device is similar to the effect of shortening the device by 2 base pairs. PMID: 22257222
  5. The results indicate that activation of the soxRS regulon in E. coli cells exposed to superoxide-propagating compounds can be triggered by depletion of the NADPH stock rather than accumulation of superoxide itself. PMID: 21178165
  6. Conformational changes induced upon reduction of DNA-bound SoxR are not significantly different from those of DNA-free SoxR. PMID: 21988663
  7. mutant SoxR proteins contributed to the multiple-antibiotic resistance phenotypes of the clinical strains and were sufficient to confer multiple-antibiotic resistance in a fresh genetic background PMID: 15980345

Show More

Hide All

Database Links
icon of phone
Call us
301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
icon of address
Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
icon of social media
Join us with

Subscribe newsletter

Leave a message

* To protect against spam, please pass the CAPTCHA test below.
CAPTCHA verification
© 2007-2024 CUSABIO TECHNOLOGY LLC All rights reserved. 鄂ICP备15011166号-1