spas Antibody

1. targeting sequence directs spastin to the surface of lipid droplets. Depletion of the homologous spastin proteins in both flies and worms affects lipid droplet number and triacylglycerol content. PMID: 25875445
2. analysis of spastin's microtubule-binding properties and comparison with katanin PMID: 23272056
3. The spastin is a key regulator of axon regeneration, and initiation of regeneration is extremely sensitive to the spastin copy number. PMID: 23122959
4. Dendritic growth is regulated by Kruppel-like factor dendritic arbor reduction protein 1 (Dar1) suppressing the expression of microtubule-severing protein spastin. PMID: 21368042
5. spastin is essential for apical domain biogenesis during rhabdomere elongation in Drosophila photoreceptor morphogenesis PMID: 20209135
6. Exogenous expression of wild-type Drosophila or human spastin rescues behavioral and cellular defects in spastin null flies equivalently. PMID: 20154342
7. Here we identify the predicted gene product CG5977 as the Drosophila homolog of the human spastin gene, with much higher sequence similarities than any other related AAA domain protein in the fly. PMID: 12908108
8. D-spastin displays ATPase activity and uses energy from ATP hydrolysis to sever and disassemble microtubules; disease mutations abolish or partially interfere with these activities. PMID: 15823537
9. X ray structure; data support a model in which spastin pulls the C terminus of tubulin through its central pore, generating a mechanical force that destabilizes tubulin-tubulin interactions within the microtubule lattice PMID: 18202664

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KEGG: dme:Dmel_CG5977

STRING: 7227.FBpp0083918

UniGene: Dm.7035