spd-2 Antibody

Code CSB-PA310487XA01CXY
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Product Details

Full Product Name
Rabbit anti-Caenorhabditis elegans spd-2 Polyclonal antibody
Uniprot No.
Target Names
spd-2
Alternative Names
spd-2 antibody; F32H2.3 antibody; Spindle-defective protein 2 antibody
Raised in
Rabbit
Species Reactivity
Caenorhabditis elegans
Immunogen
Recombinant Caenorhabditis elegans spd-2 protein
Immunogen Species
Caenorhabditis elegans
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Required both for centrosome duplication and maturation. Required for pericentriolar material (PCM) recruitment.
Gene References into Functions
  1. Intriguingly, the genetic data suggest that SAS-7 is required for daughter centrioles to become competent for duplication, and for mother centrioles to maintain this competence. SAS-7 binds SPD-2 and regulates SPD-2 centriolar recruitment, while SAS-7 centriolar localization is SPD-2-independent. PMID: 28092264
  2. Conversion of microtubule-organizing center state involves the conserved C. elegans centrosome protein SPD-2/CEP192 and cell-cycle-dependent kinase activity from the mitotic cell. PMID: 26119750
Subcellular Location
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Database Links

KEGG: cel:CELE_F32H2.3

STRING: 6239.F32H2.3.1

UniGene: Cel.5467

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