spir Antibody

1. this used Drosophila Spire (Spir) as a model system to investigate both how tandem WH2 domains can nucleate actin and what differentiates nucleating WH2-containing proteins from their non-nucleating counterparts. PMID: 25234086
2. Lola-Spir pathway is crucial for the spatial arrangement of branches within dendritic trees. PMID: 24449841
3. Data conclude that Spir plays a crucial role in controlling dorsal vessel formation and has a function in cell division during heart tube morphogenesis. PMID: 22276214
4. Multiple forms of Spire-actin complexes and their functional consequences. PMID: 22334675
5. Lola is a negative regulator of spire, derepression of spire is an important contributor to the axon stalling phenotype of embryonic motor axons in lola mutants. PMID: 22129300
6. Crystal structures of the complexes between the actin-binding WH2 repeats of the Spire protein and actin were determined for the Spire single domain D, the double (SpirCD), triple (SpirBCD), quadruple (SpirABCD) domains, and an artificial Spire (SpirDDD). PMID: 20538977
7. Drosophila protein Spire represents a third class of actin nucleation factor PMID: 15674283
8. Spire overexpression cannot rescue capu mutants, but prevents actin mesh disassembly at stage 10B and blocks late cytoplasmic streaming. PMID: 17925229

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KEGG: dme:Dmel_CG10076

STRING: 7227.FBpp0080884

UniGene: Dm.3356