spi Antibody

Datasheet

Code	CSB-PA567573XA01DLU
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Product Details
Customer Reviews and Q&A
Target Background

Product Details

Full Product Name

Rabbit anti-Drosophila melanogaster (Fruit fly) spi Polyclonal antibody

Uniprot No.

Q01083

Target Names

spi

Alternative Names

spi antibody; CG10334 antibody; Protein spitz antibody

Raised in

Rabbit

Species Reactivity

Drosophila melanogaster (Fruit fly)

Immunogen

Recombinant Drosophila melanogaster (Fruit fly) spi protein

Immunogen Species

Drosophila melanogaster (Fruit fly)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Customer Reviews and Q&A

■ Customer Reviews

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Target Background

Function

Ligand for the EGF receptor (Gurken). Involved in a number of unrelated developmental choices, for example, dorsal-ventral axis formation, glial migration, sensory organ determination, and muscle development. It is required for photoreceptor determination.

Gene References into Functions

We provide evidence that miR-8-positive glia express Spitz, a transforming growth factor alpha-like ligand that triggers epidermal growth factor receptor activation to promote neuroepithelial proliferation and neuroblast formation. PMID: 24139822
Study describes crystal structures of s-dEGFR bound to its growth factor ligand Spitz, showing how occupying one binding site in a receptor dimer impairs ligand binding to the second site in an asymmetric complex. PMID: 20723758
Argos inhibits EGFR (DER) signalling without interacting directly with the receptor, but instead by sequestering the DER-activating ligand Spitz PMID: 15329724
role for palmitoylation in restricting Spitz diffusion, allowing its local concentration to reach the threshold required for biological function PMID: 16459296
Argos mutants are deficient in their ability to bind Spitz in vitro PMID: 16870613
The size of the posterior compartment in Drosophila embryoes is due, at least in part, to cells surviving and growing according to Spi availability. PMID: 17055987
Spitz from the retina regulates genes transcribed in the second mitotic wave, peripodial epithelium, glia and plasmatocytes of the eye imaginal disc. PMID: 17553483
Germ cells signal somatic support cells via the Egf class ligand Spitz. PMID: 17629483
1.6-A resolution crystal structure of Argos bound to Spitz PMID: 18500331
interacts with Star and its function controlled by Star in the developing eye PMID: 11520660

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Subcellular Location

Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Note=Relocalization to the Golgi apparatus and the plasma membrane is mediated by Star. In the presence of Rhomboid, Spitz is found only in the Golgi, not at the cell surface.

Tissue Specificity

Expressed throughout the embryo.

Database Links

KEGG: dme:Dmel_CG10334

STRING: 7227.FBpp0080808

UniGene: Dm.4573

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