SPT4 Antibody

1. Interactions between SPT4 and RNA Polymerase II PMID: 27261007
2. Spt4/5 may be important to coordinate the mechanical movement of RNAPII through the nucleosome with co-transcriptional chromatin modifications during transcription. PMID: 28379497
3. These findings attribute a new function to a domain of Spt4/5 that associates directly with RNAPII, making significant steps towards elucidating the mechanism behind transcriptional control by Spt4/5. PMID: 27376968
4. demonstrate that physical and genetic interactions exist between Hot1 and several proteins involved in transcriptional and posttranscriptional processes: for example, transcription co-activator Sub1 and elongation complex Spt4/5 PMID: 27480106
5. Study reports that transcription of genes containing long repeats of CAG or other trinucleotides located in either protein-coding or transcribed noncoding regions of templates is selectively facilitated by the actions of Spt4 PMID: 22341442
6. Data provide evidence implicating the yeast DSIF complex (Spt4/5) and RNA polymerase II phosphorylation by Kin28 and Ctk1 in the recruitment of Rpd3S to active genes. PMID: 21060864
7. She2p interacts in vivo with the elongating forms of RNA polymerase II (pol II) via the transcription elongation factor Spt4-Spt5 PMID: 20713510
8. one function of Spt4-Spt5 is to help RNA polymerase II overcome the repressive effects of these histone modifications and chromatin regulators on transcription PMID: 19948887
9. Absence of functional Spt4p leads to altered chromatin structure at the centromeric DNA and mislocalization of the mammalian CENP-A homolog Cse4p to noncentromeric loci PMID: 15057281
10. Spt4-Spt5 complex may help coordinate splicing with transcription under conditions that present kinetic challenges to spliceosome assembly or function PMID: 16172632
11. data suggest that Spt4p, Spt5p, and, potentially, other regulators of Pol I transcription elongation play important roles in coupling rRNA transcription to its processing and ribosome assembly PMID: 16908835
12. Structural and evolutionary perspective of Spt4-Spt5 complex and suggests that it is an ancient, core component of the transcription elongation machinery. PMID: 19000817

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KEGG: sce:YGR063C

STRING: 4932.YGR063C