SPT5 Antibody

1. Interactions between SPT5 and RNA Polymerase II PMID: 27261007
2. Spt5 is crucial for a normal rate of RNA synthesis and distribution of RNAPII over transcription units. PMID: 28366642
3. High-resolution crystallographic results demonstrating that distinct structures are formed by the first through third KOW domains of Saccharomyces cerevisiae Spt5. PMID: 26217010
4. The findings suggest that Spt5 is a key coordinator for holding the RNA polymerase II complex in a closed conformation that is highly competent for transcription elongation but repressive to transcription coupled DNA repair. PMID: 24813444
5. Chromatin immunoprecipitation (ChIP) revealed that the Spt5 C-terminal region is required for normal recruitment of pre-mRNA cleavage factor I (CFI) to the 3' ends of Saccharomyces cerevisiae genes. PMID: 22290438
6. Spt5 is recruited to the rDNA early in transcription and propose that it plays an important role in ribosomal RNA synthesis through direct binding to the Pol I complex. PMID: 21467036
7. Spt5p plays both positive and negative roles in transcription by Pol I. PMID: 21467039
8. suppression of spt5 can result from loss of histone H3 lysines 4 or 36 methylation, or reduced recruitment of Chd1 or the Rpd3S complex PMID: 19948887
9. Data show that Bur1 phosphorylates the Spt5 C-terminal repeat domain (CTD) both in vivo and in isolated elongation complexes in vitro. PMID: 19581288

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KEGG: sce:YML010W

STRING: 4932.YML010W