CAO Antibody

1. CpSRP54 drives cpSRP43 to an active state, binding substrate in the H2O compartment. Bidentate interactions with Alb3 drive it to partial inactivity, selectively releasing LHCP transmembrane domains in a productive unloading complex at the membrane. PMID: 26951662
2. cpSRP43 chromodomain 3 interacts with a linear motif in the Alb3 C-terminal tail. Study describes the structural basis for selectivity of CPSRP43 chromodomains 2 and 3 for their respective ligands cpSRP54 and Alb3. PMID: 26568381
3. results support the conclusion that substrate binding to the chloroplast SRP is modulated by protein structural dynamics in which a major role of cpSRP54 is to improve substrate binding efficiency to the cpSRP. PMID: 25918165
4. The action of cpSRP43 can be dissected into two steps, initial recognition, during which cpSRP43 binds specifically to a recognition motif on the surface of the aggregate, followed by aggregate remodeling. PMID: 23519468
5. A mechanism for recognition of the LHC aggregate by cpSRP43 elucidated by a biophysical and biochemical approach. PMID: 23525109
6. cpSRP43 inserts into a dimeric Alb3 translocation pore during cpSRP-dependent delivery of light-harvesting chlorophyll a,b-binding proteins. [SRP43] PMID: 21832051
7. The authors report the crystal structure of the chloroplast signal recognition particle (cpSRP) core from Arabidopsis thaliana, with the cpSRP54 tail comprising an arginine-rich motif bound to the second chromodomain of cpSRP43. PMID: 22231402
8. study presents 1.5 angstrom crystal structure of cpSRP43 characterized by a unique arrangement of chromodomains & ankyrin repeats; complex with the internal signal sequence of LHCPs reveals that cpSRP43 specifically recognizes a DPLG peptide motif PMID: 18621669

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KEGG: ath:AT2G47450

STRING: 3702.AT2G47450.1

UniGene: At.19748